ANZCTR search results

The aim of our pilot study is to assess the feasibility of direct non-invasive brain stimulation (transcranial direct current stimulation) use during an exercise intervention to improve pain and functional outcomes in people with Achilles tendinopathy. Specifically, we seek to examine the integrity of the study protocol, the acceptability of the intervention and to inform sample size calculations for a future large scale randomised controlled trial.

This is an open-label, formulation bridging and food-effect study which will compare 2 formulations in 3 separate crossover steps, as well as the effect of food (low-fat vs. high-fat diet). Who is it for? You may be eligible for this study if you are aged 18 to 65 years living with overweight or obesity, have a with a body mass index of greater than or equal to 27kg and less than 45kg without clinically significant (CS) medical history. Study details The aim of this study will be to assess the relative bioavailability of 2 formulations of aleniglipron in overweight or obese participants.

The AUSCA patch is a non-invasive diagnostic tool that uses adhesive tape to stay insitu whilst in use. The patch can record, heart, lung and pulse waveforms using sound waves. The main aim of the study is to assess the ability of the AUSCA patch to record various observations, waveforms and haemodynamic measurements during rest and exercise of patients with cardiac disease. We would also like to analyse the waveforms gained from the AUSCA patch on patients who have an implanted Mechanical Circulatory Support (MCS) Device to gain more insight into the pump's function.

The aims of this study are to investigate new and novel models of care to improve ease of access to HCV testing and treatment for people who inject drugs (PWID) within community pharmacies. The study will evaluate the effectiveness, economic impact, and sustainability of outreach nurses collaborating with community pharmacists who dispense Opiate Agonist Therapy (OAT). Building a network of community pharmacies engaged in hepatitis C testing and care will improve access to diagnosis and treatment for people who inject drugs, leading to higher rates of diagnosis, treatment initiation, and cure in a cost-effective and sustainable way.

Marine omega-3 oils have a short shelf life and poor bioavailability due to oxidation. This instability limits their effectiveness and increases manufacturing costs due to the need for softgel encapsulation and stabilising aids. There is a clear industry need for a solution that extends shelf life, improves bioavailability, and enables more versatile product formulations. NETech has developed a proprietary technology that converts marine oils into a stable powder form, significantly reducing oxidation and increasing bioavailability. This technology eliminates the need for additional stabilisers and softgel formats, offering a purer and more versatile omega-3 product compared to existing technologies. This project aims to compare the effect of consuming mussel oil and mussel powder on plasma omega-3 polyunsaturated fatty acid levels.

Serious injury is life changing yet trauma care and research has typically focused on survival rather than survivorship. Over 90% of people survive serious injury. Throughout their recovery, they will need to navigate a myriad of health and social services. Many of these services are underpinned by complex funding mechanisms and eligibility criteria that can differ by demographics, cause and geography. Survivors of serious injury have identified the absence of a single point of contact for navigating and coordinating post-discharge care as a consistent barrier to recovery. We will trial a Trauma Patient Navigator (TPN) model to enhance patient and carer experience and improve the quality of survival. The Advancing Care Through Injury Outcome Navigators (ACTION) study is a Type 2 hybrid effectiveness-implementation design using a balanced staircase stepped wedge cluster randomised control trial (RCT, n=1,344) to be conducted across Victoria, New South Wales, Queensland, Tasmania, South Australia, and Western Australia. We will systematically evaluate the effectiveness and adoption of TPNs to address the endemic complexity of health and social systems faced by survivors of serious injury to improve post-discharge care and support, health-related quality of life and trauma outcomes. This project will test the feasibility, effectiveness and cost-effectiveness of the TPN intervention which directly addresses a critical need defined by survivors of serious injury and their close others. The findings will transform post-discharge trauma care and deliver the necessary evidence and implementation toolkit to achieve widespread adoption within trauma clinical practice and policy in Australia.

This randomised control trial will compare the effects of topical non-steroidal anti inflammatory drug (NSAID) to a sham topical gel in people with painful foot osteoarthritis (OA). The primary objective is to determine whether daily use of a topical NSAID gel leads to significantly greater reductions in foot OA pain with walking, compared to a sham gel, at 6 weeks. The secondary objectives are to determine whether daily use of a topical NSAID gel leads to significantly greater benefits on other clinical outcomes (physical function, other measures of foot OA pain, global ratings of change, health-related quality of life, and physical activity levels), compared to a sham gel, at 6 weeks, and evaluate the extent of use and clinical outcomes in a subsequent 6 week follow up period when use was deemed as needed, at 12 weeks.

The AWASH study aims to investigate the feasibility of applying an antibiotic wash to the bowel during surgery, with a short course of post-operative irrigation in some patients, for adults having planned colorectal surgery where the bowel is rejoined. Who is it for? You may be eligible for this study if you are an adult undergoing elective colorectal resection with primary anastomosis. Study details Participants will be randomly allocated to receive either the study treatment or standard care. The study treatment involves washing the bowel during surgery with antibiotics, and for patients undergoing an anastomosis within 15cm of the anus, a trans-anal drainage tube will be placed intra-operatively to facilitate antibiotic washing on postoperative days 1 and 2. Outcomes on success of delivery of the treatment and patient complications will be collected. It is hoped that findings from this study will help clinicians and researchers determine whether the intervention and study processes can be delivered safely and successfully to inform a larger future trial.

This Phase 1 study is testing a new drug called NB-9402. The study drug NB-9402 is being developed by Nura Bio Inc, as a potential treatment for diseases of the nervous system. The study will evaluate the potential drug-drug interactions of NB-9402 with repaglinide and midazolam.

This Phase 1 study is testing a new drug called NB-9402. The study drug NB-9402 is being developed by Nura Bio Inc. as a potential treatment for diseases of the nervous system. This study will assess the safety and tolerability of NB-9402 when given as single and multiple oral doses in healthy adult volunteers.