ANZCTR search results

When surgeons perform weight-loss sleeve gastrectomy, they remove most of the stomach to leave a narrow tube, but there is little agreement on what the ideal size and shape of the remaining stomach should be, and it is not known how much this varies between surgeons or changes over time. This study follows adults having sleeve gastrectomy with several different surgeons and uses three-dimensional CT scans of the stomach taken before surgery and again over the following five years to measure its size and shape in a standardised way. We will compare these measurements between different surgeons and within the same surgeon to see how much variation exists, and how the stomach changes over time. We will also look at whether these anatomical measurements relate to weight loss and to reflux symptoms. The aim is to define what a standard, well-constructed sleeve looks like, which could help make the operation more consistent and improve patient outcomes.

Some people who have weight-loss (sleeve gastrectomy) surgery later develop troublesome acid reflux, and when medication does not control it surgeons can offer revision surgery: repairing a hiatus hernia on its own, or repairing it and converting the stomach to a gastric bypass. This study follows adults having this revision surgery as part of their usual care and measures whether their reflux improves. Before surgery and again afterwards we compare each patient's acid-reflux test results (pH monitoring) and their reflux symptom (Visick) scores, and we record any complications, whether anti-reflux medication is restarted, and satisfaction with surgery. There is no separate control group; each participant acts as their own comparison, and we also compare the two revision approaches. We expect revision surgery to reduce both acid exposure and symptoms, which will help patients and surgeons choose between the two revision options.

The aim of this project is to support pre-service teachers’ holistic health during their final in-school teaching placement. Non-controlled trial The studies hypothesis is that by participating in physical activity and zooms the pre-service teachers may have better physical activity patterns, mental health and social support whilst on placement.

This project is piloting Shared Medical Appointments (SMAs) — group-based sessions that bring together individual clinical care, education, and peer support — for women with endometriosis at the WSIH MyHealth Integrative Medical Centre in Western Sydney. We will test this program to see how well it works and whether people find it helpful and easy to take part in. What we learn will help us create ongoing group integrative SMAs for women with endometriosis at WSIH MyHealth, including programs tailored to specific cultural groups. It will also help guide similar group programs for other women's health conditions.

This is a phase 2b, multi-centre, double-blind randomised controlled trial evaluating psilocybin-assisted psychotherapy (PAT) for methamphetamine use disorder (MAUD). One hundred and twenty treatment-seeking adults with MAUD will be randomised 1:1 to receive either PAT with a single 25 mg oral dose of psilocybin or PAT with a single 5 mg oral dose of psilocybin, with both groups receiving the same structured preparatory and integration psychotherapy. The primary outcome is the number of days of methamphetamine use in the 28 days prior to week 12 post-randomisation, assessed using Timeline Follow Back methodology and supported by urine drug testing. Secondary outcomes include methamphetamine abstinence and remission, other substance use, craving, mental health, sleep, quality of life, functional impairment, safety, acceptability, feasibility and cost-effectiveness. Participants will be followed to 52 weeks, with an optional open-label 25 mg psilocybin-assisted psychotherapy treatment offered after the week 16 assessment.

This randomised controlled trial aims to compare the effectiveness of three types of fixed orthodontic retainers in maintaining lower front tooth alignment after orthodontic treatment. Participants will receive either a CAD/CAM 0.026-inch stainless steel retainer, a CAD/CAM 0.018-inch stainless steel retainer, or a conventional multi-stranded stainless steel retainer. All participants will also receive a standard lower removable vacuum-formed retainer. The study will assess post-treatment tooth stability as the primary outcome, as well as retainer failure, periodontal health, and patient satisfaction. We expect to determine whether the CAD/CAM retainers provide similar or improved stability and clinical outcomes compared with the conventional fixed retainer.

This pilot study will compare three pain-treatment approaches in children aged 2–16 years with burn injuries: standard care with paracetamol, paracetamol plus celecoxib, and paracetamol plus ibuprofen. The study will assess whether celecoxib and ibuprofen can be used safely in these children and whether they reduce inflammation, pain and the time required for burn wounds to heal. It will also examine whether the treatments affect the need for skin grafting, scar outcomes and post-traumatic stress symptoms. We hypothesise that children receiving celecoxib or ibuprofen will have less inflammation and improved healing outcomes compared with children receiving paracetamol alone, without an unacceptable increase in adverse effects.

This study aims to find out whether listening to artificial intelligence (AI)-generated ambient music or AI)-generated binaural beats can reduce stress in adults undergoing cataract surgery while awake under a sub-tenon eye anaesthetic block. The researchers expect that participants who listen to AI-generated ambient music or binaural beats will experience lower levels of stress than participants who do not receive an audio intervention. The study also aims to determine whether these interventions can improve recovery, reduce the need for anxiety-relieving or pain-relieving medications, and shorten the amount of time spent in hospital after the procedure. Participants will be randomly assigned to one of three groups: AI-generated ambient music, AI-generated binaural beats, or a comparison group that wears headphones without any audio. Stress will be measured using brain activity monitoring, blood pressure, heart rate, breathing rate, and questionnaires completed before and after surgery. Hospital stay and medication use will also be reviewed from clinical records. The results of this study may help identify safe, low-cost, non-drug approaches to reducing stress and improving the surgical experience for people undergoing cataract surgery.

Insulin therapy is recommended in gestational diabetes when dietary changes have not adequately controlled blood glucose levels. The purpose of this study is to compare the effectiveness of two different types of insulin that we use in treating gestational diabetes, Optisulin® and Novomix30®, in managing fasting blood glucose levels.

This study will compare two exercise programs for adults aged 40 to 64 years to determine whether multi-planar functional training is more effective than machine-based strength training for improving balance performance and physical function during midlife. Participants will be randomly allocated to either a machine-based strength training program or a multi-planar functional training program, completed twice per week for 12 weeks at HSCfit, Hunter Sports Centre. Balance performance will be assessed using force plate technology, and lower limb muscle strength and power will be assessed using a countermovement jump test performed on force plate technology. The findings will help inform exercise approaches that may support early prevention of age-related balance decline and future falls risk before older age.