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The purpose of this study is to investigate the feasibility, safety and acceptability of a Pilates exercise intervention for adults living with advanced cancer. Additionally, the aim is to also understand the impact of a Pilates exercise intervention on the strength, balance, physical activity, quality of life and sleep quality of adults living with advanced cancer. Who is it for? This study is for adults aged 18 years and older living with a confirmed diagnosis of an advanced cancer who are able to attend and perform Pilates in-person and on-line (telehealth) across 8 weeks. Participants must not currently be engaging in structured exercise for more than 2x per week over the previous 3 months. Study details Participants will be randomised to either attend Pilates intervention or to continue to receive usual care. Participants allocated to the Pilates intervention will undertake 2x 60 minute supervised mat-based Pilates sessions per week for 8-weeks, delivered by a certified Pilates instructor who is also an accredited exercise physiologist. Sessions are in a small group format of up to 3 participants per class, and each week one of the two sessions will be delivered in-person (face-to-face) while the second session will be delivered on-line (telehealth). Participants in this study will completed a variety of physical tests, including but not limited to: grip strength test, sit-to-stand test, up-and-go test, balance. Participants will also be asked to complete questionnaires to assess quality of life, sleep, and physical activity. It is hoped that the findings from this study will help determine whether Pilates could become a practical component of cancer rehabilitation programs and inform the design of a larger clinical trial.

Mobile phones are ubiquitous in healthcare settings as patients, visitors and healthcare workers use them frequently. Mobile phones can carry harmful microbes in healthcare settings, especially in the intensive care unit, and may potentially be putting patients at risk of contracting healthcare-associated infections. Therefore, mobile phone sanitisation solutions are required for healthcare settings, and ultraviolet-C (UV-C) devices offer a promising solution to this problem. However, it is yet to be investigated whether healthcare workers will be willing to use UV-C devices frequently to disinfect their phones at work. Hence, this study aims to implement a UV-C device in a real-world intensive care unit, and evaluate whether it is accepted and utilised by healthcare workers.

The aim of this study is to investigate the dentoskeletal effects of Align Technology™ Invisalign treatment with Mandibular Advancement with Occlusal Blocks (MA-OB) in comparison with historical data on a traditional functional appliance, the Twin-block, in growing adolescents with a small jaw. The study hypothesis is that there is a significant difference in dental and skeletal effects from the Invisalign MA-OB orthodontic appliance, compared to effects from using conventional functional appliances. There are no studies to date which have investigated the efficacy of the updated Invisalign MA-OB appliance. Therefore, the aim of the present investigation is to evaluate the effects of Invisalign MA-OB and compare it with the conventionally used functional appliance, the Twin-block.

Many people with diabetes develop nerve damage in their feet and lower legs that causes ongoing pain, often described as burning, stabbing or electric shock-like, which is frequently not well relieved by medication. This study is testing whether adding a simple flashing light, synchronised with the pulses of a TENS (Transcutaneous Electrical Nerve Stimulation) machine, changes people's experience of that pain compared with TENS on its own.

The aim of this study is to determine the immediate impact of flexible adhesive film on CPRS-related allodynia. The key study questions for this project includes: 1) For patients with allodynia as a result of CRPS, does applying flexible adhesive film to part of affected upper limb immediately impact: a. tolerance of light touch with tissue (assessed via numerical scale questionnaire) b. pressure-pain threshold (assessed via pressure algometer) 2) For patients with allodynia as a result of CRPS, does flexible adhesive film immediately diminish the response to thermal stimulus: a. thermal detection threshold (QST machine) 3) For patients with allodynia as a result of CRPS, does applying flexible adhesive film immediately influence ability to complete a patient-identified functional task: a. Patient rated functional scale (0-10)

Who is it for? This study will investigate whether breathing muscle strength training can be safely and successfully completed before major head and neck cancer surgery. You may be eligible for this study if you are aged 18 years or older, you have been diagnosed with head and neck cancer and the planned treatment for your cancer is surgery followed by radiotherapy. This study will specifically enrol people who already have a respiratory condition and those who are expected to need a tracheostomy as part of their surgery. Study details All participants who choose to enrol in this study will be given a small handheld device to strengthen the muscles used for breathing and coughing before surgery. Participants will be shown how to use the device and will then be asked to complete 5 sets of exercises using the device each day before their surgery. At 4-6 weeks after surgery, participants will be asked to start using the device to complete exercises each day for the duration of their radiotherapy. This may be as few as 3 weeks or up to 6 weeks, depending upon the radiotherapy course. It is hoped this research will determine whether breathing muscle strength training can be safely delivered to people undergoing surgery for their head and neck cancer and whether this training is able to improve breathing, swallowing and tracheostomy-related outcomes after surgery.

This study evaluates MiM Primary Care, an online training programme designed to help GPs, nurses, pharmacists, and rural generalists better engage men in their care. Men are less likely to seek help early for health problems, and this training aims to build practitioners' knowledge, confidence, and skills in recognising and responding to men's health needs. We expect that completing the training will improve practitioners' knowledge and confidence in engaging male patients, measured using a purpose-built survey. All participating practitioners complete the training and are surveyed before training, immediately after, and again 12 weeks later, with no separate comparison group. The study will also examine whether the training is practical, acceptable, and likely to be adopted across different primary care settings.

This study is testing whether a simple daily self-care practice is realistic and manageable for busy health professionals — such as psychologists, counsellors, nurses, and other allied health practitioners — who often experience high levels of work-related stress. The practice, called SERF (Sensory Engagement and Reflective Practice for Flourishing), involves preparing and drinking a cup of herbal tea each day while doing a short breathing and reflection exercise, followed by a brief written reflection. Twenty-four health professionals will be randomly assigned to drink either Lemon Balm tea or Rooibos tea, alongside the same daily practice, for 28 days. Findings will help us design a bigger study and understand whether this kind of low-cost, self-guided practice could support the wellbeing of Australia's health workforce

This study aims to determine whether guselkumab is more effective than optimising current medical treatment for adults with stricturing Crohn's disease. Participants will be randomly assigned to receive either guselkumab or optimise their existing advanced medical therapy. We will compare how well these treatments improve bowel strictures, reduce the need for surgery, and improve symptoms and quality of life. We expect that guselkumab will be more effective at treating bowel strictures and slowing disease progression. This is the first randomised controlled trial specifically designed for people with stricturing Crohn's disease, a group that has largely been excluded from previous clinical trials.

Midline laparotomy closure techniques strongly influence postoperative wound outcomes, particularly incisional hernia, a frequent and clinically significant complication associated with pain, functional impairment, and reoperation. This is especially relevant in emergency laparotomy, where patients are physiologically compromised and at higher risk of contamination, infection, and impaired healing. We conduct this trial to compare small-bites versus large-bites fascial closure in emergency laparotomy to determine whether the benefits observed in elective and mixed surgical populations translate to this higher-risk setting.