ANZCTR search results

This study will investigate whether combining computerised cognitive training (CT) with intermittent theta burst stimulation (iTBS), a non-invasive brain stimulation technique, can improve memory, executive function, and brain function in older adults with mild cognitive impairment (MCI). Participants will be randomly allocated to receive CT with iTBS, CT with sham (inactive) iTBS, or a waitlist control. We hypothesise that CT combined with iTBS will lead to greater improvements in cognitive function and brain activity compared to CT alone or no intervention.

This study will take place at several locations designed to look and feel like a home setting. It aims to check how well the new iHealth rapid test can identify influenza A, influenza B, COVID-19, and RSV using nasal swabs taken by people with symptoms, by comparing the results to those from highly accurate laboratory tests. The study will include over 500 people with cold or flu-like symptoms, making sure to include both young children (6-23 months) and older adults (above 60 years) with RSV.

Psychedelic medicine has emerged as a safe and promising therapeutic approach for a wide range of mental and physical health conditions. Psychedelics like psilocin facilitate profound psychological experiences that can interrupt rigid, maladaptive thought patterns commonly underlying chronic and treatment-resistant mental illnesses. This open-label study will evaluate the safety and preliminary effects of a novel intravenous (IV, i.e. into the vein) formulation of the psychedelic psilocin (TRP-8803) in 10 different mental and physical health conditions (Anorexia Nervosa, Body Dysmorphic Disorder, Chronic Fatigue, Fibromyalgia, Generalized Anxiety Disorder, Irritable Bowel Syndrome, Long COVID, Major Depressive Disorder, Obsessive Compulsive Disorder, Post Traumatic Stress Disorder). Eligible participants will complete two doses of TRP-8803, administered in conjunction with psychotherapy over a treatment period of 6 weeks, and followed up until 12 weeks post second dose.

This study will evaluate the safety and clinical effectiveness of the ROMAX Resurfacing System in primary hip resurfacing. This will be achieved by assessing survivorship and collecting patient reported outcome measures from patients receiving the ROMAX resurfacing system. Patient clinical and radiographic outcomes will be analysed pre-implantation and post-implantation through to 3 years. The hypothesis is that the 2-year cumulative percent revision of the ROMAX resurfacing system is not inferior to the performance of other resurfacing systems currently on the Australian market.

A pilot randomised trial that will test the feasibility and preliminary efficacy of the podcast-based intervention in a group of Australian men (aged 18-70 years) that are experiencing at least mild psychological distress (e.g., depression, anxiety and stress). Online assessments will collect data for primary outcomes (e.g., feasibility such as, podcast listenership & satisfaction) and secondary outcomes (e.g., psychological distress, attitudes towards help-seeking) at baseline, and 10-weeks (post-intervention, primary endpoint).

This study aims to explore the functionality and acceptability and feasibility of a novel immersive virtual reality gamified rehabilitation therapy programme, the Spatialist VR (SVR) for adult patients with an acquired brain injury and visuospatial neglect. The study will be completed in two phases. This phase will evaluate the acceptability of the SVR therapy programme and explore the feasibility of a future larger RCT, including sample size calculation by using a pilot RCT model.

This study aims to explore the functionality and acceptability of a novel immersive virtual reality gamified rehabilitation therapy programme, the Spatialist VR (SVR) for adult patients with an acquired brain injury and visuospatial neglect.

Follitropin delta is a safe and effective medication to use in ovulation induction prior to intrauterine insemination or frozen embryo transfer with acceptable pregnancy, cycle cancellation, ovarian hyperstimulation syndrome and multiple pregnancy rates. The purpose of the retrospective observational cohort study is to report patient and treatment characteristics and outcome for patients where follitropin delta was used.

This phase I study aims to recruit healthy volunteers. Participants will be enrolled in 2 groups of 6 each (3 men and 3 woman). Each participant will attend 2 treatment sessions and receive two different formulations of Keticap®. In Period 1, Participants will be randomised to receive either a single dose of KET-IR (160 mg) or single dose of KET-AD (160 mg) in the first study session. Following at least 7 days wash-out period the participants will receive the alternate formulation to the one received in period 1second formulation in the final study session.

Patients recovering from heart surgery in the ICU often experience high stress, anxiety, and confusion, which can lead to lasting psychological effects like PTSD or depression. While medications are commonly used, they can have side effects and may not be fully effective, prompting interest in non-drug approaches such as music or guided imagery. Virtual Reality (VR) offers an immersive and calming experience and has shown promise in reducing anxiety in healthcare settings, but its structured use in ICUs remains limited. This Australian study will be the first to prospectively test an interactive, gamified VR program for heart surgery patients in the ICU. It will evaluate the intervention’s safety, effectiveness, usability, and acceptability from both patients and staff, with findings to be published and shared widely.