ANZCTR search results

Failure to provide vocational support after stroke costs Australia $3.6 billion in lost productivity yearly. Vocational support in Australia is limited to return to work (RTW) support in some rehabilitation services. This results in significant service gaps, particularly in rural and remote communities. We have co-developed a telehealth post-stroke Work Support Program designed to ensure vocational support needs are met any time throughout the RTW and long term work participation journey. We will conduct a randomised controlled trial comparing the Work Support Program to usual care to determine if the program results in a significantly greater improvement in work ability. We will recruit 194 stroke survivors across Australia, collecting work ability and other vocational and wellbeing outcomes by telephone at baseline, 3, 6 and 12-months post baseline; evaluate cost efficacy, and conduct a process evaluation to examine factors that will impact on translation.

The current study aims to deliver and evaluate a new telehealth, psychologist-led cancer-related fatigue ) treatment program in women with ovarian cancer, called REFRESH-Ovarian. Who is it for? You may be eligible for this study if you are an adult female with ovarian cancer who lives in a rural and remote area of Australia, and are experiencing mild-to-severe levels of cancer-related fatigue. Study details The program will screen and offer treatment to people with ovarian cancer experiencing mild-to-severe levels of cancer-related fatigue, in the form of a (i) workbook based on cognitive behavioural therapy (CBT) principles and (ii) psychologist support (e.g., phone-coaching and/or group CBT). Data on the acceptability, feasibility and appropriateness of the study will be collected. It is hoped that findings from this study will help inform future interventions for cancer-related fatigue and also address the health disparities faced by people with ovarian cancer and people living in rural and remote areas.

This study investigated whether the belief a healthcare practitioner holds about the treatment they are delivering influences the pain relief their patient experiences. Forty-five adults with knee pain attended a single appointment at one of two clinics in Adelaide and were each treated by one of twelve qualified practitioners; all patients received the same sham (non-penetrating) dry needling treatment. Practitioners at one clinic were told they were delivering real dry needling; practitioners at the other clinic were told they were delivering sham dry needling, while patients in both arms were informed they had a 50/50 chance of receiving real or sham dry needling. We hypothesised that patients treated by practitioners who believed they were delivering real dry needling would experience greater reductions in pain at rest and movement-evoked pain than patients treated by practitioners who knew they were delivering sham dry needling. Pain at rest and movement-evoked pain were assessed before treatment, immediately after treatment, and at 24-hour follow-up, with pressure pain thresholds also measured before and after treatment.

This study is investigating if a physiotherapy led assessment and management service based on a stepped care framework where people are referred to the most appropriate exercise service for their needs, for people with prostate cancer is feasible as compared to usual care without physiotherapy assessment and management. Who is it for? You may be eligible for this trial if you are aged 18 years or over, within 6 months of prostate cancer diagnosis and living independently in the community. Study details Participants will be randomly allocated to one of two groups: 1) Physiotherapist delivered stepped care for exercise; or 2) usual care without physiotherapy. At 6 months after you start the study, data regarding quality of life, physical capacity and health service utilisation will be collected. It is hoped this study will determine the feasibility of a steeped model of physiotherapy care aimed at improving physical activity levels after prostate cancer diagnosis.

This research aim is to explore the use of Traditional Medicine in children, with a focus on children from Aboriginal and Torres Strait Islander and Culturally and Linguistically Diverse (CaLD) families. It also aims to explore barriers and enablers to parental disclosure on the use of Traditional Medicine when they present to emergency departments and clinicians’ knowledge attitudes and perceptions on Traditional Medicine.

This is a Phase 1 study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ZE74-0282 in patients JAK2 V617F mutated hematologic diagnosis who have undergone prior therapy or who have declined this. Who is it for? You may be eligible for this study if you are aged over 18 years old with a confirmed JAK2 V617F mutant hematologic malignancy and have previously received or have declined prior therapy. Study details The study will be run in 2 parts: Part 1 will be dose escalation and determination of maximum tolerated dose (MTD) in patients with select hematologic malignancies that have JAK2 V617F mutations. Part 2 will be dose expansion to identify the optimal and recommended phase 2 dose (RP2D) of ZE74-0282. ZE74-0282 will be administered orally once daily or twice daily in continuous 28-day treatment cycles. Treatment may continue for up to 24 cycles. Participants will undergo regular safety assessments, including vital signs, blood and urine tests, and other clinical evaluations. Eligibility criteria for both Part 1 and Part 2 is the same, however participants enrolled in Part 1 of the study will not be permitted to enrol in Part 2 of the study. It is hoped this research will determine the maximum RP2D dose of ZE74-0282 that can be administered safely without causing severe reactions. Following completion of the expansion portion of the study and identification of the RP2D, based on the safety and efficacy data, the study may be amended to transition to different cohorts of disease, earlier lines of therapy and combination therapies.

Individuals suffering Parkinson's disease (PD) often exhibit the symptom of hypomimia, known as facial masking. This symptom is characterised as difficulty in changing facial expression in response to different emotions and is evident as a secondary sign of PD in the early stages of the disease process. Analysis of facial expressions recorded via video is a non-invasive and promising diagnostic tool for the early detection of PD. This study proposes to use expression analysis recorded as a video utilising computer vision and machine learning techniques as a non-invasive method to identify Parkinson's disease. Data collection for the PhD project was completed December 2024 for this project with a final reported submitted and approved by RMIT HREC 24/10/2024. Data collection continues as part of the broader project which includes: ACTRN12623000220662 A comparative clinical study of a handwriting app for the diagnosis of Parkinson's disease for people living in rural and remote communities. A comparative study between people with early to mid-stage Parkinson's disease and age-matched healthy volunteers ACTRN12623000219684 A comparative clinical study of a voice recording app for the diagnosis of Parkinson's disease for people living in rural and remote communities. A comparative study between people with early to mid-stage Parkinson's disease and age-matched healthy volunteers.

Despite the potential for exercise as an effective therapeutic approach for people with gastrointestinal (GI) disorders, often studies on exercise and GI disorders explore the patient’s well-being and disease activity without objective inflammatory markers. To strengthen the development of exercise as a management strategy, the acute exercise-induced response and interaction with GI disorders warrants investigation. Therefore, the purpose of this study was to investigate the acute exercise-induced inflammatory response in individuals with GI disorders; specifically, IBD and IBS, and compare these responses to healthy controls (HC). We hypothesis that people with GI disorders will elicit an acute anti-inflammatory response with an increase in the post exercise period (immediately and 2h post).

The aim of this study is to investigate the acceptability, feasibility and preliminary efficacy of a Hub-and-Spoke, Peer-led communication aphasia group program in a regional health setting. A mixed-methods, waitlist control, randomised controlled trial and process evaluation was used. Participants included a minimum 12 people with aphasia and 12 close others, with each pair randomly allocated to either the treatment or control arm. By drawing on trained peers from the community the Hub-and-Spoke, Peer-led CAG model offers a way to address the specific challenges faced by people living with aphasia. Hub-and-Spoke, Peer-led CAGs hold potential to improve access to tailored community-based supports for people with chronic aphasia.

This study aims to investigate the optimal duration of on-shift naps during night shifts to improve safety and productivity. While on-shift naps can boost performance at night, they may temporarily reduce alertness upon waking and require additional downtime away from work tasks. In a controlled laboratory setting, participants will complete four conditions in a within-subjects, repeated measures, counterbalanced design: no-nap; 15-min nap; 30-min nap; 60-min nap. We hypothesise that increasing the duration of naps will result in an overall increase in whole of shift performance and productivity, despite greater short-term safety impairment from sleep inertia post-nap. The findings will support evidence-based guidelines for on-shift napping to support workplace productivity and safety with minimal disruption to operational efficiency.