ANZCTR search results

This study aims to find out whether following a healthy eating plan that includes anti-inflammatory foods can help improve pain, quality of life, and health in people with osteoarthritis. Participants will be randomly assigned to one of two groups: one group will follow the Australian Dietary Guidelines (Healthy Diet A), and the other group will follow the same guidelines plus additional anti-inflammatory foods (Healthy Diet B). Both diets will be supported by regular sessions with dietitians over 12 weeks. The study will measure changes in pain, physical function, quality of life, mood, sleep, and blood markers of inflammation. We hypothesise that the group following the anti-inflammatory diet will experience greater improvements in quality of life, pain, and inflammation compared to those following the standard healthy eating plan.

Period pain and symptoms impact many facets of young people’s lives. Early intervention in young people is critical to reducing the lifelong personal and societal impacts of period pain and symptoms and potential secondary causes such as endometriosis. However, problematically, young people do not know how to determine the normality of their menstrual pain, and the severity of impact that requires self management and help-seeking. Timely detection and early intervention for problematic period pain and symptoms may improve the health and wellbeing of young people. The purpose of this research is to conduct a randomised, controlled, three arm pilot trial to investigate the feasibility and acceptability of two web-based menstrual impact screening interventions compared with a control, in young people (14-25 years) with period pain and symptoms.

Endoscopic Lung volume Reduction (ELVR) is an established treatment for severe Chronic Obstructive Pulmonary Disease (COPD). Endobronchial valves are an accepted management option for achieving lung volume reduction, but are not suitable for every patient. Over 50% of patients are unable to have one way valves because of anatomical deficits ('fissures') in the lobes of the lung. Patients with >95% fissure completeness are eligible for valves; patients with 80-95% fissure completeness are further assessed for possible valve options but currently in Australia, there are no therapeutic options for patients with fissure completeness < 80%. This study seeks to expand the ELVR technique to patients not suitable for ELVR with standard approaches (such as endobronchial valves) by using segmental delivery of a polymer foam sealant called AeriSeal ® in patients with a fissure completeness < 80% for the targeted lobe. Polymer sealant allows lung volume reduction in these COPD patients who have no other alternatives.

This pragmatic pilot feasibility study evaluated the real-world implementation of PainPLaN, a co-designed pain science education resource, by physiotherapists in private practice settings with patients experiencing chronic or recurrent pain. The overarching aim of this study was to assess the feasibility, use, acceptability, satisfaction, and feedback on potential improvements for the resource, as reported by both physiotherapists and patients.

This study aims to find out whether stopping inhaled corticosteroid (ICS) puffers for a longer period before a breathing test makes the test more accurate in diagnosing asthma. Many people use ICS puffers regularly to control asthma symptoms, but these medicines can temporarily reduce airway sensitivity and may cause false-negative results when testing for asthma. In this study, adults referred for a bronchoprovocation (breathing challenge) test will be randomly assigned to withhold their ICS medication for either 72 hours (standard practice) or seven days, with some extending to three weeks if needed. Researchers will then compare how often the test correctly detects asthma between the groups. The study’s main hypothesis is that longer ICS withholding periods will improve the sensitivity and accuracy of asthma testing. Findings from this research may help refine national testing guidelines and improve how asthma is diagnosed and managed in clinical practice.

This is a FIH randomized, double-blind, placebo-controlled study of the safety, tolerability, PK, and PD following single and multiple intravenously or subcutaneous doses of CLD-423 in healthy adult participants

This study is investigating whether a mobile app called Gro Health can help people with type 2 diabetes improve their health. The app provides education and support to help users make changes to their diet, physical activity, sleep, and mental wellbeing. Adults with type 2 diabetes will be randomly assigned to receive access to the Gro Health app for 6 months in addition to their usual care, or to continue with usual care alone. After 6 months, the control group will be offered access to the app. The main outcome is to see whether using the app improves blood glucose levels (HbA1c) over 6 months, as well as other health measures like cholesterol, weight, and blood pressure.

The Black Dog Institute has co-developed a youth-focused self-harm prevention program, Bridge to Better (B2B), along with a complementary parent/carer intervention, Parenting to Prevent (P2P), to address rising rates of adolescent self-harm in Australia. The primary aim of this pilot trial is to test the efficacy of the P2P web-based intervention in improving parent knowledge of emotion regulation strategies and skills in autonomy-supportive parenting. Secondary aims include assessing the impact of P2P on self-harm literacy and stigma, program implementation outcomes (acceptability, feasibility, credibility, expectancy, engagement), and the effectiveness of digital recruitment strategies compared to traditional flyer distribution. The trial uses a three-arm cluster randomised design with 264 parents of NSW primary school students (grades 3–6) enrolled in the B2B trial, randomised at the school level into one of three recruitment pathways: physical flyer, digital flyer, or trial link embedded in child B2B consent form. All parents receive the same P2P program, consisting of eight YouTube videos and weekly activities delivered via a website over 8 weeks. Outcomes will be assessed at baseline and post-intervention, with qualitative interviews conducted with a subsample of parents to explore integration of P2P into routine parenting.

People coming into the Transition Care Program (TCP) are invited to participate in a research project. In collaboration with Metro South Health in Queensland, and the University of Queensland, we are conducting a study to understand goals, activity patterns and other health data relevant to older people who enter the TCP following their stay in hospital. We will use Fitbits to collect activity and health data. You will also be asked to do some additional health assessments when you first start TCP and when you exit TCP. The purpose of this study is to examine how much TCP clients’ move around each day and to see how this is related to their goals, health and quality of life outcomes throughout the program. Future benefits for TCP clients’ may include improved clinical monitoring and patient care, as well as better goal attainment and health outcomes.

Both hypercapnic respiratory failure and acute kidney injury (AKI) are common problems in Intensive Care Units (ICUs). When either or both are severe, organ support in the form of non-invasive ventilation (NIV), mechanical ventilation (MV) and continuous renal replacement therapy (CRRT) are sometimes required. In some of these patients, extracorporeal carbon dioxide (CO2) removal (ECCO2R) may also be required. Although there has been detailed description of circuit pressures and filter life in CRRT, there is no published clinical data affecting the adequacy of treatment with ECCO2R and circuit haemodynamics and filter life when ECCO2R is combined with CRRT or used as standalone without CRRT. Our group have published a case series of patients where ECCO2R was used in conjunction with CRRT. The main complication noted in this study was circuit clotting within 72 hours of initiation of ECC02R. Circuit clotting can lead to poorer delivered treatment doses, requirement of red cell transfusion due to blood loss and increased resource requirement for re-commencement of therapy. It is unclear if the circuit haemodynamics and filter life, is impacted by the way ECCO2R is delivered i.e. ECCO2R in conjunction with CRRT compared to standalone ECCO2R or conventional CRRT. This research investigates the circuit haemodynamics and filter life and its clinical effects