ANZCTR search results

This study is a Phase 1, randomized, single-masked, multiple ascending dose (MAD) study designed to evaluate the safety, tolerability, and preliminary efficacy of pregabalin (PRG) ophthalmic solution in patients diagnosed with Primary Open-Angle Glaucoma (POAG) or Ocular Hypertension (OHT). The study will be conducted at up to 3 clinical sites and will include up to 32 participants, divided into 4 escalating dose cohorts. The study will employ a single-masked design, meaning that the evaluating investigator and subjects will remain unaware of the treatment allocation, while other study personnel, including the sponsor, Safety Review Committee (SRC), and medical monitor, will be unmasked. The comparator arm will use XALATAN (latanoprost ophthalmic solution), a well-established drug used for lowering intraocular pressure (IOP). This study aims to determine the safety profile of pregabalin eye drops and to explore its effects on IOP and corneal sensitivity over a three-day treatment period.

This research study is to compare the user experience with Omnipod 5 and ‘usual care’ in people living with type 1 diabetes. This study will be unique in that it will assess the user experience with automated insulin delivery (AID) enabled pod therapy across the lifespan of those with T1D from young children, through adolescence to adulthood and older adulthood, using closely aligned methodology. We hypothesise that Omnipod 5 use will be associated with a positive user experience and improved quality of life and other psychosocial measures compared to ‘usual care’ with multiple daily injections and tubed insulin pumps.

Obesity is a growing health issue, and current treatments are often expensive or not widely available. This study is testing whether dexamphetamine, an older and affordable medication, can safely and effectively help people lose weight when combined with diet and lifestyle changes. Participants in the study will either receive dexamphetamine or a lookalike placebo for six months, with regular check-ins to monitor health and support lifestyle habits. The medication dose will be carefully adjusted based on individual response and safety, and participants will be followed for two years after treatment ends. If successful, this research could lead to a more accessible and cost-effective way to manage obesity in everyday healthcare settings.

This study aims to examine the neurobiological underpinning of body image dissatisfaction in women aged 18-35 years old, and whether Eye Movement Desensitization and Reprocessing (EMDR) therapy is effective and acceptable in reducing body image dissatisfaction in this population. Through accessing secondary data from individuals with low levels of body dissatisfaction, we will compare neurological responses to images of self and other to a high body dissatisfaction group collected as part of this study, It is hypothesised that there will be neurobiological differences in those with high and low body image dissatisfaction. Further, it is hypothesised that EMDR will be effective at reducing distress associated with body image memories.

This study aims to assess the ProtonPetal Alpha One’s ability to track potassium levels at rest, when compared to current on market PoC reference measurement devices. Findings from this trial will guide future clinical evaluations and device refinement.

The aim of this study is to compare outcomes between two splints used after surgical repair of flexor tendon injury, namely the forearm-based dorsal blocking splint and Manchester short splint. Outcomes will include patient-reported hand function and quality of life, and clinician-reported range of motion and grip strength.

Targeting peripheral airway dysfunction with small particle bronchodilator in asthma This study aims to determine whether the small airways, a site of physiological dysfunction in asthma, can be targeted with bronchodilator therapy, by using a small particle size aerosol that reaches the lung periphery. Current clinical management of patients with asthma includes an array of inhaled therapies. However, there is no consensus relating to the efficacy of different particle sizes for inhalation, despite particle size being the main determinant of where the drug deposits in the airway. Participants with asthma will be invited to participate in two study visits. Both study visits will involve physiological assessments (lung function tests) and ventilation scans completed at baseline and post-bronchodilator. At one visit the standard medication salbutamol will be administered via a conventional vibrating mesh nebuliser (Aerogen solo), at the other visit the salbutamol will be administered via the Aerogen PDAP which will create a fine particle aerosol. The aim is 2 recruit and test 30 participants and compare their response to small and large particle bronchodilator.

The Mothers Heart Study is an observational prospective cohort study. In this study we recruit pregnant women prior to <16 weeks of gestation to study the association between early pregnancy cardiometabolic risk factors and risk for coronary heart disease at 6 months postpartum.

Purpose of study: Fruits and vegetables are known for their many health benefits, with research suggesting they may improve respiratory and inflammatory outcomes in people with COPD, However the relationship between fruits and vegetables and COPD is still being explored. This study aims to compare fruit and vegetable intake in participants with COPD versus healthy control participants, with the goal of identifying any significant differences in fruit and vegetable intake between the two groups. By comparing fruit and vegetable consumption levels, this study aims to explore whether individuals with COPD tend to consume fewer servings compared to people without COPD, potentially due to factors related to their COPD, such as reduced appetite, physical limitations, or lifestyle changes influenced by symptoms of their condition. We hypothesise that participants with COPD consume significantly fewer serves of fruits and vegetables compared to healthy controls, and a higher fruit and vegetable intake is associated with fewer respiratory symptoms in individuals with COPD.

Asthma is a serious but manageable condition. We will evaluate whether a digital platform and mobile app co-designed by consumers, clinicians, and researchers reduces asthma hospitalisation in a disadvantaged community. Our model of care empowers patients, their families, and health care professionals to optimise the management of asthma, thus improving outcomes, saving lives, and reducing healthcare costs.