ANZCTR search results

This study aims to better understand eating disorders by examining the biological, psychological, social, and neurological factors that contribute to their development, maintenance, and recovery. People aged 14 and over with a current or past eating disorder will be invited to take part in a series of assessments, including surveys, interviews, cognitive tasks, brain imaging, and biological sample collection. By collecting this information, the study hopes to identify patterns and individual differences that could help improve early identification and develop more personalised and effective treatments in the future. We hypothesise that eating disorders are influenced by a combination of genetic, brain-based, behavioural, and environmental factors, and that understanding these in greater detail will lead to better outcomes for individuals affected by these conditions.

We aim to study the levels of hormones and the clotting tendency of blood whilst a patient is on oral oestrogen and compare it to when they are on sublingual oestrogen. This will help us gain a better understanding of the comparative risk of a VTE whilst on sublingual oestrogen and the efficacy of sublingual oestrogen for transgender women. At this stage, we are hoping to include about 30 trans women on feminising gender affirming hormone therapy.

This study is designed to investigate how a specialised PET/CT scan using 89Zr-girentuximab can assist in detecting and evaluating tumours that express a protein known as CA-IX. The goal is to determine how this scan compares with standard diagnostic approaches and whether it improves treatment planning for certain cancers. Who is it for? This research is suitable for adults aged 18 years and older with a suspected or confirmed diagnosis of clear cell renal cell carcinoma (ccRCC), mesothelioma, or another cancer type expected to express CA-IX. Participants must be medically stable, able to provide informed consent, and have an expected survival of more than three months. Study details Participants referred by their treating doctor will undergo a PET/CT scan using the imaging agent 89Zr-girentuximab at the Melbourne Theranostic Innovation Centre. All eligible participants will receive the scan as part of the study. Clinical teams will compare results from this scan with other routine imaging tests, biopsy results, and clinical outcomes over a 12-month period to assess its accuracy and usefulness. Additional follow-up will involve reviewing medical records and may include phone interviews to evaluate treatment decisions. It is hoped that the result from this study will demonstrate the clinical impact of girentuximab, highlighting its value in the management of patients with CAIX expressing tumours.

This project aims to examine the feasibility, efficacy, safety and acceptability of a Mediterranean diet intervention for improving mental wellbeing and quality of life in Autistic Adults living in Australia. It utilises a 6-week pilot randomised control trial design with a wait-list control group. While previous trials have shown a positive effect of dietary interventions for improving mental wellbeing in the general public, it is not known if these findings will translate to autistic adults. It is expected that a personalised approach to implementing a Mediterranean diet - which accommodates sensory/personal needs and preferences of autistic adults, will result in high feasibility and acceptability among participants.

Emerging evidence suggests that sleep quality at night may influence how short of breath people with COPD (chronic obstructive pulmonary disease) feel during the daytime. The effects of reduced sleep on breathlessness in COPD have not been assessed. Therefore, this study aims to investigate the effects of reduced sleep duration on breathlessness and exercise capacity, as measured by cycle ergometer cardiopulmonary exercise testing, in people with COPD. Outcomes will be assessed via a randomized, controlled, crossover clinical trial design.

Incubator humidification is currently widely used in the care of premature infants to assist with thermal stability, however, hypothermia continues to be an ongoing problem as optimal thermal weaning practices remain unclear as a result of lack of evidence. Alternative durations of incubator humidification can have differing effects on thermal stability, electrolyte imbalance and skin injury. The primary aim of of this trial will be to determine whether there is a difference in the infant's thermal stability between stopping incubator humidification at 168 hours vs stopping at 96 hours vs gradually weaning incubator humidification from 96 hours to 168 hours. Understanding if there are differences will support the development of a new evidence based protocol for managing incubator humidification.

The CardioCharge Trial is a hybrid effectiveness-implementation trial (type II) that aims to demonstrate that evidence-based post-discharge DHI support can be integrated, funded and systematised as part of routine clinical treatment for patients with CVD across diverse health care settings This study is a national, multi-site implementation and evaluation of an evidence-based post-discharge DHI for patients after a hospitalization for CVD. The primary objective is to evaluate the effectiveness of post-discharge digital support on representation to hospitals, testing the primary hypothesis that a 6-month program of a personalised digital health intervention (i.e. intervention) for post-discharge cardiology patients will lower all-cause re-hospitalisation, as compared to a single bundle of digital support (i.e. control). The secondary objectives are to evaluate the role of telephone detailing to improve uptake of the program, machine learning in improving personalisation and retention to the program, and to evaluate the cost-effectiveness of the program.

Informal carers of people who have experienced a stroke often face high levels of stress, anxiety, and depression, however, there are few tailored support options available to address their unique needs and priorities. Supporting these carers is critical, as their wellbeing directly impacts the recovery and quality of life of stroke survivors. This study aims to explore the feasibility and acceptability of a 12-week tailored support package designed for informal stroke carers. The findings will also help determine whether the intervention is practical and valued by carers to inform the design of future, larger-scale trials.

To determine in patients with premature ventricular complexes (PVCs) if catheter ablation is more efficacious than medical therapy to reduce PVC burden and improve cardiac function, symptoms, and quality of life. Primary Hypothesis Catheter ablation is more effective at reducing PVC burden and associated symptoms, improving quality of life and cardiac function compared to medical therapy alone.

This study aims to assess the benefit of accessing 16 weeks of IT in addition to standard care for people with traumatic neurological spinal, brain or proximal limb injury when transitioning from being an inpatient to outpatient. We propose that people will experience improved management of their mental health and wellbeing, pain, physical function, and socialisation than those who do not undertake IT.