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When men have surgery for a blocked prostate (called TURP), they often notice that they no longer ejaculate during orgasm. This is commonly assumed to be because semen travels backwards into the bladder instead of forwards, a condition called retrograde ejaculation. However, it is possible that the cause is actually that semen is not produced at all during orgasm (anejaculation). These two conditions look the same from the outside but have different implications, particularly for men who wish to have children in the future. This study will use a simple urine test after orgasm to objectively determine which of these two conditions is occurring in men who have had TURP. It will also assess whether this urine test is practical enough to be used routinely in clinical care.

Randomised 3×3 crossover; each participant completes three fasted morning visits with unilateral EIMD (limb alternation; adequate washouts). Post-exercise breakfast (within 30–45 min): whole eggs, egg whites, or whey (protein-matched, macronutrient and energy matched). Outcomes: VAS soreness and strength recovery over 72 h recovery window, bio-markers of muscle damage (CK) and mechanisms (post-prandial amino acid profiles and fatty acid profiles in a subset of participants).

Brief description of the study purpose This study aims to find out whether simple text message reminders from a general practitioner (GP) can encourage young adults to learn about and receive the human papillomavirus (HPV) vaccine, which helps prevent certain cancers. Who is it for? This study is for young adults aged 18 to 25 who are patients at a participating GP clinic and are eligible for a catch-up HPV vaccination but have not yet completed it. Study details Participants will be randomly assigned to one of two groups. One group will receive three text messages from their GP over three months, encouraging them to learn about and consider getting the HPV vaccine. The other group will continue with usual care for six months and will then receive the same text messages later. These messages are sent directly to the participant’s mobile phone through GP clinic software. The study will also monitor whether messages are successfully delivered and whether participants respond. Routine health records from the GP clinic may be used to determine whether participants go on to receive the HPV vaccine. Medical records will be used to determine the number of participants who end up getting the recommended vaccine. Survey and interviews will be used to identify facilitators, barriers and other factors for future scale-up of the intervention. It is hoped that this research will show whether simple, low-cost text message reminders from GPs can increase HPV vaccination rates and help prevent HPV-related cancers in young adults.

This project will pilot Story-ABI-lity, a novel, co-designed speech pathology intervention for adults with traumatic brain injury (TBI). Story-ABI-lity is a manualised narrative intervention developed in collaboration with people with TBI and multidisciplinary clinicians, specifically designed for the inpatient rehabilitation context. Despite this setting providing the greatest opportunity for intensive, early intervention, there are currently no programs specifically designed to address communication impairments in hospital. Communication impairments following TBI are often persistent and limit the ability to participate in conversations and communicate needs clearly, impacting engagement in rehabilitation and long-term social relationships. Story-ABI-lity targets everyday narratives by integrating metacognitive strategy training with structured storytelling intervention, grounded in established theoretical and evidence-based frameworks.

Cohorts 2 and 3 are double-blind, randomized, placebo-controlled studies evaluating the safety, tolerability, and PK of multiple SCY-770 doses in 8 participants (3:1 randomization). Progression to Cohort 3 depends on SRC review of Cohort 2 data. Cohort 3 uses sentinel dosing, with 2 participants dosed first, followed by the remaining 6 participants if safety is confirmed. Cohort 2 – SCY-770 750mg QD for 7 days Cohort 3 – SCY-770 500mg BID for 6 days and SCY-770 500mg QD on Day 7:

Cohort 1 (single-dose food effect evaluation) follows a randomized crossover design comprising three treatments, with a 4-day washout period between administrations of SCY-770 (administered on Study Days 1, 5, and 9): Treatment 1: Single 500 mg dose of SCY-770 under fasted conditions Treatment 2: Single 500 mg dose administered 15 minutes before the start of a standardized breakfast, to be consumed within 30 minutes Treatment 3: Single 500 mg dose administered 30 minutes after the start of a standardized breakfast, to be consumed within 30 minutes Upon completion of Cohort 1, the Sponsor will determine the dosing regimen for Cohorts 2 and 3 based on Cohort 1 PK results. The finalized dosing instructions will be documented in a Protocol Clarification Letter (PCL) and in Version 2 of the Study Pharmacy Manual, without requiring a protocol amendment.

A collaborative research project to implement and test a virtual care referral pathway for paramedics to manage people with back pain. The project is a collaboration between the Institute for Musculoskeletal Health, and established health services, including Sydney Virtual Hospital and NSW Ambulance. Back pain is a common presentation to Australian ambulance services. Currently, ~30% of patients with back pain who are managed, discharged to stay at home and referred by paramedics to community health services for follow-up care reconnect with emergency health services. Virtual care services are a new alternative to in-person hospital care, providing high-quality care remotely to patients with back pain, to reduce hospital admission. This research program will involve a number of projects including a randomised controlled trial and economic evaluation, and qualitative research. The research project aims; to implement and test a virtual care referral pathway for paramedics to manage people with back pain. The RAMBO trial will evaluate the effectiveness of the virtual care pathway on health service outcomes, such as ambulance transport to hospital (primary outcome), presentation to the emergency department, patient re-contact with ambulance service, re-presentation to the emergency department and admission to hospital. The trial will also evaluate patient outcomes, including pain intensity, physical function and satisfaction with care. The economic evaluation will evaluate the cost-effectiveness of the virtual care referral pathway compared to usual care delivered by paramedics (e.g. transport to hospital) from a healthcare funder perspective. The nested qualitative research will explore; i) the clinician's perspectives of the virtual care referral pathway, and enablers and barriers to its use, and ii) the patient's views and satisfaction with the virtual care that they received for their back pain. The findings from the program of research will be translated into practice, through our partnership with health services and the Sydney Local Health District.

A common method of cooling used in endurance sports is additional skin wetting (applying water to the skin), including through water dousing (pouring water over the body). Placing additional water on the skin through dousing effectively acts as non-biological sweat which can increase the skin wettedness (% of skin covered by water) of an individual and potentially improve heat loss through a greater evaporative capacity. This study seeks to determine if dousing improves the rate of cooling during recovery from exercise, whilst also directly comparing against cold water ingestion.

This study will test whether a brief online guided imagery exercise can help reduce maladaptive perfectionism in first-year university students. Participants will be randomly allocated to complete either an audio-guided imagery rescripting exercise or an audio-guided positive imagery exercise. They will complete online questionnaires before and after the exercise, and again after receiving their academic results.

This pilot evaluation will generate empirical evidence on the efficacy of the SCMH program in supporting parents of children from CALD backgrounds. The findings will also generate critical cultural considerations necessary to optimise the program’s relevance and appropriateness within CALD communities, which may lead to greater uptake of the course and better effects in CALD communities in Australia and internationally.