ANZCTR search results

This study is investigating whether antibiotics that are usually given through a vein can instead be given under the skin (subcutaneously) in children. Giving antibiotics under the skin (subcutaneously) may reduce the need for intravenous lines, reduce complications, and improve comfort. Participants will receive their prescribed antibiotic through both methods in a randomised order. Blood samples will be collected to assess antibiotic blood levels in the body with each method. The study will also assess safety, pain and acceptability of each method.

The aim of this project is to develop, implement, and evaluate a consumer co-designed physical activity promotion program for community-dwelling individuals with moderate-to-profound disability. Through an extensive program of consumer engagement and stakeholder consultation, we will modify our efficacious best practice PA promotion model for people with disability - the Adapted Physical Activity Program (APAP) so it can be applied to support individuals with moderate-to-profound disabilities (APAP-OMNI). For implementation, we will co-design a workforce capacity and capability building training package to enable allied health professionals to deliver APAP-OMNI at scale in their own communities. We will evaluate the impact of the program in an Type 1 hybrid effectiveness-implementation cluster randomised trial and develop training resources to facilitate dissemination of the program to other communities. APAP-OMNI will improve access to safe and effective PA promotion services for people with disabilities who are currently under-served.

A common method of cooling used in endurance sports is additional skin wetting (applying water to the skin), including through water dousing (pouring water over the body). Placing additional water on the skin through dousing effectively acts as non-biological sweat which can increase the skin wettedness (% of skin covered by water) of an individual and potentially improve heat loss through a greater evaporative capacity. There is a need for well-designed controlled experimental studies into the effect of water dousing which mimics the demands (intensity) and features (air velocity) of competitive long-distance cycling.

Patients admitted to General Medicine often have complex health needs, and some are unexpectedly readmitted to hospital soon after going home. This study aims to see whether using an electronic tool that estimates a patient’s risk of re-admission, together with a more consistent approach to discharge planning, can reduce unplanned re-admissions within 28 days. The tool uses information already collected during routine care and supports, but does not replace, clinical judgement. In this trial, both groups receive the same formalised, standardised model of care; the intervention group additionally receives the AI-generated re-admission risk score to support prioritisation. Patients will not be asked to do anything extra as part of the study, and no consent form is required because the study is low risk and part of standard care. All patient information will be handled securely and confidentially.

New blood tests for detection of Alzheimer’s disease (AD), the most common cause of dementia, are becoming available, but are not yet approved for clinical use in Australia. Will they help GPs to diagnose the cause of memory problems? This study, run by the Australian Dementia Network and funded by the Commonwealth Department of Health and Aged Care, aims to answer this question. Participants are invited to take part in this research project because they have presented to their General Practitioner (GP) or practice nurse with concerns about cognition (i.e. memory or thinking). This research project will test if the new blood test for AD trial will help GPs to make a more confident and faster diagnosis of Alzheimer’s disease in patients in the early stages of this disease.

Musculoskeletal conditions such as chronic low back pain and osteoarthritis are leading causes of pain and disability worldwide, and many people also experience poor sleep. This study will investigate whether adding cognitive behavioural therapy for insomnia (CBT-I) to usual physiotherapy care improves pain and sleep outcomes compared with usual physiotherapy care alone. The SLEEP-MSK trial is a two-stage adaptive basket randomised controlled trial involving people with chronic low back pain, hip osteoarthritis or knee osteoarthritis and insomnia. Participants will be randomly allocated to receive either usual physiotherapy care alone or usual physiotherapy care plus CBT-I delivered by trained physiotherapists. Outcomes including pain, insomnia severity, physical function, fatigue and quality of life will be assessed over 12 months.

This study is a staged feasibility and pilot RCT evaluating a brief, self-directed, online Earth care intervention designed to support the mental health and well-being (MHWB) of adults experiencing ecological distress. In this study, ecological distress is defined as persistent, negative emotional responses related to climate change and environmental degradation. The intervention is informed by relational values and Tronto's (2013) stages of care, reframes ecological distress as morally important information, and supports participants in translating their distress into adaptive, locally relevant acts of care. The study follows the Medical Research Council's (MRC) framework for designing and evaluating complex interventions and includes pre-pilot testing, a randomised waitlist-controlled trial, and an embedded process evaluation. Outcomes focus on feasibility, acceptability, psychological and ecological distress, self-efficacy for environmental action, mental well-being, and human-nature relationships.

This study aims to improve the healthiness of food and drink options available in sports and recreation settings. Many food outlets in these settings sell unhealthy food and drinks, which can influence people’s food choices and contribute to poor diet and health. The study will test whether providing food retailers with a suite of digital tools can help them make healthier changes. These tools will support retailers to assess their current food offerings, receive tailored recommendations, and monitor progress over time. Food outlets will be randomly assigned to either use the digital tools or continue with their usual practices. The study will compare changes in the availability of healthier drinks and food options, as well as purchasing patterns. It is hypothesised that food outlets using the implementation-supporting digital tools will increase the proportion of healthier food and drink options available and may improve purchasing patterns compared to those continuing standard practice. The findings will help determine whether digital tools can support healthier food environments in community settings and inform future public health strategies.

This study aims to improve the management of patients admitted to the Hospital in the Home (HITH) program with heart failure by integrating lung ultrasound into clinical assessment and treatment decisions. Lung ultrasound is more accurate than physical examination or chest X-ray in detecting pulmonary congestion, which means detecting fluid in the lung that is often missed using conventional methods. Studies have shown that incorporating lung ultrasound significantly improves fluid detection, leading to better-guided therapy. To generate the necessary evidence for implementing this technique, this study will compare standard heart failure management with an approach that incorporates lung ultrasound. A total of 110 participants will be enrolled, with half receiving lung ultrasound and the other half following usual care. Key outcomes, including hospital readmission rates, length of stay in the HITH program, and medication adjustments, will be assessed and compared between groups. This research will provide valuable data on the potential benefits of lung ultrasound in optimising heart failure treatment in home-based care settings.

Brief description of the study purpose This study aims to find out whether the medication olanzapine can help reduce weight loss in people with head and neck cancer receiving combined chemotherapy and radiotherapy given with curative intent. Who is it for? You may be eligible for this study if you are male or female age 18 or over, with head and neck cancer who are planned to receive combined chemoradiotherapy, are able to eat by mouth, and are well enough to take part. Study details Participants in this study will take olanzapine 2.5 mg by mouth once daily for 12 weeks, starting up to two weeks before chemoradiotherapy and continuing during and after treatment. All participants receive active treatment with olanzapine in addition to their standard chemoradiotherapy; there is no randomisation. Outcomes will be compared with past patients who received standard care alone. Participants will have regular clinical assessments, including monitoring of body weight, symptoms, and routine blood tests as part of their cancer treatment. It is hoped that the results from this study will show whether olanzapine is safe and can help reduce weight loss in people with head and neck cancer receiving combined chemotherapy and radiotherapy.