ANZCTR search results

This study tests whether a short online intervention about how food supports the brain and body can reduce unhealthy eating thoughts and behaviours in young adults aged 18 to 25 who are concerned about their weight. It builds on an earlier trial, using an updated intervention designed to be more engaging and to support healthy body image. Participants will be randomly assigned either to complete the intervention, which includes nutrition education and a planning exercise, or to complete questionnaires only. Aims: 1. Does a functional nutrition single-session intervention reduce disordered eating and improve body image flexibility, relative to assessment-only control, in young adults aged 18 to 25 years with elevated weight concern, at one and four weeks post-randomisation? 2. Does the intervention improve depression, anxiety, suicidal ideation, hope, eating disorder behaviours, psychological distress and regular carbohydrate intake, relative to control, at one and four weeks post-randomisation?

Older adults who return home from hospital after an injury can have unmet needs for information, support and services during their recovery. This study tested whether a telephone-based navigator service, delivered by clinically trained navigators (physiotherapists), was feasible and acceptable for adults aged 65 years or over discharged home from a South Australian trauma service. Thirty participants were offered up to eight calls over the four weeks after discharge, in which the navigator helped them understand their discharge information, monitor their recovery and find relevant health and community services. The study measured recruitment, delivery of the calls, acceptability, the needs identified and how navigators responded to them. It also assessed measures of function, quality of life and care transitions for use in a future evaluation and the findings will inform the design of the service and of a larger service and study.

This study aims to determine whether a risk-adjusted approach to breast cancer screening using Contrast-Based Imaging modalities (MRI or CEM) may particularly benefit women with higher mammographic breast density by increasing screening sensitivity. Who is it for? This study is for: * Both female and male BreastScreen Victoria clients aged 40-70 years * With a clear most recent routine mammographic screening, and * Who have been assessed as being at higher risk of breast cancer based on either 1) their family history (as recorded by BreastScreen Victoria) and Category C breast density; OR 2) Category D breast density (regardless of family history). Study details BreastScreen Victoria (BSV) clients will be randomly allocated (by chance) to either: Group 1. An invitation to supplemental screening tests using either magnetic resonance imaging (MRI) or Contrast Enhanced Mammography (CEM) or Group 2. No invitation to supplemental screening tests. In the group allocated to receive an invitation (Group 1), they will be further allocated to have either magnetic resonance imaging (MRI) or Contrast Enhanced Mammography (CEM) depending on their age and breast density. That is: Allocation to supplemental screening using MRI: * Clients aged 50-55 with Category D breast density or * Aged 40-49 regardless of breast density or family history Allocation to supplemental screening using Contrast Enhanced Mammography (CEM): * Clients aged 50-70 with Category C breast density and potentially high risk of developing breast cancer due to family history or * Aged 55-70 with Category D breast density. Feasibility, acceptability and cost-effectiveness of supplemental imaging will be determined from recruitment rates, imaging attendance and questionnaires assessed at 3 months after consent to the study. It is hoped that risk-adjusted breast cancer screening program is feasible, will be acceptable by BreastScreen clients, will be cost-effective for the Australian healthcare system, and will lead to earlier detection of clinically significant breast cancers, a reduction in interval cancers and reduced breast cancer mortality.

Lumbar spinal stenosis is a common condition in older adults that can cause pain, difficulty walking, and reduced quality of life. This study will evaluate whether a chiropractor-led Lumbar Spinal Stenosis Boot Camp program can be safely and effectively delivered within an integrated tertiary spine care service in Australia. Forty adults aged 60 years and older with lumbar spinal stenosis will participate in a 6-week program consisting of education, manual therapy, exercise, and self-management advice. The study will assess feasibility by examining recruitment, consent, retention, treatment attendance, data collection procedures, safety, and the integration of chiropractors into tertiary spine care pathways. The study will also collect preliminary information on changes in symptoms, physical function, walking ability, quality of life, and health care use to inform the design of a future larger clinical trial.

This observational study investigates whether a bacterium called MAP is associated with Crohn's disease and how it relates to changes in gut bacteria. We will compare 30 Crohn's patients (followed for 6 months) with 30 healthy controls, testing blood, stool, and bowel biopsies taken during endoscopy (standard care). We expect to find that MAP is more common in Crohn's patients and associated with an imbalance of gut bacteria that changes with treatment over time. This research could lead to better diagnostic tests and new treatment approaches for Crohn's disease. Participation involves brief interviews, blood and stool samples, and endoscopy with biopsies at baseline and 6 months for Crohn's patients; controls provide one-time samples.

Disturbances in cerebral blood flow and intracranial pressure may alter blood flow through collateral vessels connecting the intracranial and extracranial circulations. Some of these vessels are superficial and can be assessed non-invasively using Doppler ultrasound. This prospective observational study will investigate whether arterial and venous Doppler signals can be reliably obtained from superficial extracranial vessels in critically ill patients with suspected disturbed cerebral haemodynamics. Participants will undergo non-invasive Doppler ultrasound assessments of vessels including the superficial temporal and supraorbital/supratrochlear circulations. Up to three examinations may be performed during the first seven days following enrolment. Doppler waveform characteristics will be compared with clinical diagnosis, intracranial pressure where available, neurological findings and clinical outcomes. The primary aim is to determine the feasibility of obtaining adequate Doppler signals in this patient population. Secondary exploratory analyses will investigate whether extracranial Doppler waveform characteristics are associated with disturbances in cerebral haemodynamics and neurological outcomes.

People with spinal cord injury often sleep poorly. One reason is that spinal cord injury can disrupt the body’s ability to control temperature, and temperature control is one way the body prepares for sleep. This project will examine the efficacy of a home-based temperature-controlled mattress topper in 20 adults with chronic spinal cord injury using a randomised crossover design, with participants completing a 21-night usual-sleep condition and a 21-night mattress-topper condition separated by a three-night washout. Sleep will be estimated using a consumer smart ring, with morning questions, skin temperature measurements and questionnaires assessing sleep, insomnia, mood and wellbeing. We expect the mattress topper to improve sleep and overnight comfort, particularly for people with higher-level spinal injuries.

To pilot a brief intervention for family members of people with hoarding disorder to ensure the intervention is feasible and improve family member coping.

Vial Australia Pty Ltd is conducting a first-in-human study of VIAL-IL13xTSLP, an experimental bispecific antibody that targets two inflammatory proteins (IL-13 and TSLP) involved in asthma. The study will evaluate the safety, tolerability, and biological effects of the drug in patients with mild-to-moderate asthma.

This study is Part 3 of this Phase 1 study. Part 1 is ACTRN12626000320358 and Part 2 is ACTRN12626001173381. Part 3 evaluates the effect of fluvoxamine on the PK and safety of ATH434 in healthy volunteers. The primary hypothesis is that co-administration of fluvoxamine will not significantly change the systemic exposure of a single 50 mg dose of ATH434. The study also aims to confirm the safety and tolerability of combining these treatments, using a fixed-sequence crossover design to compare ATH434 levels with and without fluvoxamine.