ANZCTR search results

Many people receiving dialysis feel lonely or cut off from others, and social prescribing connects people with activities, groups and services in their local community. This pilot study will test whether a social prescribing program is feasible for adults receiving dialysis at four units in Western Sydney, Australia. Fifty participants will be randomly assigned to one of two groups: the social prescribing program, or their usual care. In the program, a link worker with lived experience of kidney failure makes a plan with each person to join one or two community activities and calls them regularly over 3 months. We expect that at least half of eligible patients will agree to take part and at least 8 in 10 will stay in the study to 3 months; we will also measure loneliness, social isolation, life participation, fatigue, hospital admissions, changes in dialysis type, survival and costs.

This project focuses on improving the way non-surgical multidisciplinary team (MDT) management is matched to the needs of patients with chronic musculoskeletal pain, such as low back, shoulder or knee pain, in the Queensland Musculoskeletal Physiotherapy Screening Clinic and Multidisciplinary Service (MPSC&MDS). A service improvement initiative (MATCH), has been developed to better align MDT referrals with patient needs and to enhance patient engagement with care. This pilot and feasibility trial will evaluate the impact of implementing MATCH at four MPSC&MDS sites (approximately 458 patients). Outcomes will include the appropriateness of MDT referrals, patient engagement, patient-reported health outcomes, health service utilisation and costs, and the feasibility and fidelity of implementing MATCH within routine service delivery. Findings from this trial will inform the feasibility and design of a future, larger-scale evaluation of MATCH across the state-wide MPSC&MDS.

Endometriosis is a common condition that can cause ongoing pelvic pain, tiredness and reduced quality of life. This study aims to find out whether an 8-week group dance program called “Dance for Me” is a safe, enjoyable and practical exercise option for people with endometriosis. Twenty people with endometriosis will take part in one 45-minute group dance class each week for eight weeks, with movements adapted to how participants feel and what they are able to do. We expect that most participants will be able to attend and complete the program and will find it acceptable and safe. The study will also explore whether participants report changes in pain, tiredness, wellbeing and quality of life after completing the program. The results will help us decide whether the program should be tested in a larger study in the future.

This pilot study is evaluating a rapid multidisciplinary assessment pathway (RADAR) with molecular profiling-guided targeted therapy and/or immunotherapy to assess progression-free survival in patients with anaplastic thyroid cancer Who is it for? You may be eligible to join this study if you are aged 18 years or above, have a histopathologically confirmed diagnosis of anaplastic thyroid cancer diagnosed within New South Wales, have been referred to the Department of Diabetes, Endocrinology and Metabolism, Royal North Shore Hospital, and are able to provide informed consent. You will not be eligible if you are pregnant or within six weeks of giving birth, or if your diagnosis is advanced differentiated or poorly differentiated thyroid cancer that does not meet the criteria for anaplastic thyroid cancer. Study details All participants will receive the Rapid Access for Diagnosis, Assessment, and Response (RADAR) pathway on diagnosis or clinical suspicion of anaplastic thyroid cancer. A multidisciplinary team of endocrinologists, medical oncologists, endocrine surgeons, anatomical pathologists, radiation oncologists and palliative care physicians is convened within 24 hours on weekdays or 48 hours on weekends, coordinated by a designated surgical registrar. A tumour biopsy is taken quickly and tested for genetic changes, with the first results available within 24 hours and full results within a week. These genetic results tell the team which treatments are most likely to work for that person. Depending on what is found, the team recommends particular targeted drugs, immunotherapy, surgery or radiotherapy. The drugs themselves are not provided by the study; they are prescribed as part of normal clinical care, and access is arranged individually for each person. Overall survival, side effects, quality of life, the cost-effectiveness of treatment, and how quickly each step of the pathway happens will also be assessed at regular intervals. It is hoped that assessing and treating people this quickly, and choosing treatment based on the tumour’s genetic profile, will mean more people are alive and free of cancer growth six months after diagnosis than has been the case for patients treated at our hospital in the past.

The primary aim of this prospective cohort study is to audit compliance with perioperative diabetes guidelines for patients undergoing elective surgery in Australia and Aotearoa New Zealand. Secondary aims include exploring associations between concordance with guideline recommendations and incidence of postoperative complications.

This study aims to investigate the effectiveness of graded sensorimotor retraining compared with i) supervised exercise and ii) guideline care for people with chronic low back pain in primary care clinical settings (Physiotherapy and Exercise Physiology clinics). Primary aim: • To determine the effect of graded sensorimotor retraining on the dual primary outcomes disability and pain intensity for adults with chronic non-specific low back pain compared to (i) supervised exercise and (ii) guideline care at 18 weeks post randomization. (Primary effectiveness evaluation) Secondary aim(s) • To determine the effect of graded sensorimotor retraining on secondary outcomes disability (26 and 52 weeks post randomization), pain intensity (26 and 52 weeks post randomization), recovery (18 and 26 weeks post randomization), quality of life, global perceived effect, pain interference, back beliefs, health care and medication use, work related outcomes, adverse events and serious adverse events at 18, 26 and 52 weeks post randomization. (Secondary effectiveness evaluation) • To investigate the cost-effectiveness and cost utility of graded sensorimotor retraining from a societal and health systems perspective. (Economic evaluation) • To investigate the implementation of graded sensorimotor retraining, determining: (i) implementation outcomes (acceptability, appropriateness, fidelity and implementation cost; and (ii) contextual barriers and facilitators to implementation. (Implementation evaluation)

Children often experience significant pain, stress, and fear during medical procedures in emergency departments (EDs). While medicines help, many children still feel distressed. New approaches such as virtual reality (VR) may offer additional support by using headsets to immerse children in interactive games and stories that distract them from painful procedures. VR shows promise but is not yet widely used in paediatric EDs. This project will investigate whether VR is practical, effective, and affordable across three very different Queensland hospitals: Queensland Children’s Hospital (tertiary), Caboolture Hospital (urban), and Kingaroy Hospital (rural). Phase 1 will involve parents, children, nurses, and doctors working with researchers to design how VR should be integrated into routine ED care, select suitable VR content, and develop staff training resources. Phase 2 will test VR in real ED settings through a randomised controlled trial to measure children’s pain and distress, parent satisfaction, staff feedback, and stress hormone levels using simple saliva tests. This project aims to provide clear evidence on how VR can reduce children’s pain and distress in emergency care, ensuring ALL children receive the best support.

This study aims to evaluate the feasibility of a digital stress-mindset intervention for construction workers, with a secondary aim of examining preliminary changes in perceived stress. The intervention adopts a stress-as-enhancing framework, educating participants about stress responses and the role of stress mindsets in reframing stress experiences. Feasibility outcomes will include recruitment, retention, and measure completion, while intervention effectiveness will be assessed using the Perceived Stress Scale at baseline and post-intervention

This open label, safety, acceptability and feasibility trial aims for determine whether two doses of Pomaglumetad methionil (2 X 40mg, 80mg in total) per day over a 12-week period is safe, acceptable and tolerable in young people aged 18-25 years with first-episode psychosis (i.e., the first onset of a psychotic disorder in the lifetime of an individual, FEP) or at clinical high risk for psychosis (i.e., a state in which specific predictive criteria are met which indicate that the person has an increased chance of transitioning to a psychotic illness in the future, CHR). Safety of dose and administration will be determined using safety bloods, side effects profile and treatment-emergent adverse events. Acceptability/tolerability will be assessed using recruitment and retention rates, protocol adherence (including medication adherence), stakeholder acceptability, and time to discontinuation. Secondary/exploratory aims will investigate changes from baseline after 12 weeks of treatment at full study dose in total symptomatology and dysfunction, positive and negative symptoms, quality of life and functioning. Target engagement of the investigational product will be assessed with MRI (optional component).

We propose this trial to test a modified MST and the gold standard BCTT in healthy children aged 8 –18 years . The modified protocol front-loads early increments and slows higher-intensity increments to better match BCTT exertion profiles. The perceived level of exertion and HR measured during the new Modified Shuttle Test (MST) will correlate with those measured during the Buffalo Concussion Treadmill Test (BCTT) in children without concussion.