ANZCTR search results

The aim of this study is to test if Physta® can improve hormone profiles, body composition and muscular strength in middle-aged men. It is hypothesised Physta® will increase total testosterone (and associated hormones), muscular strength, fat free mass and decrease fat mass in middle-age men compared to men who use a placebo.

The main aim of this study is to find out whether starting a specialised pain relief treatment early,using a local anaesthetic delivered continuously through a small catheter near the nerves around the ribs,provides better pain control and improves recovery for people aged 65 years and older who have multiple rib fractures on one side of the chest. The study will compare these patients with a similar group who receive standard pain management using medications alone (such as tablets or injections), without any nerve-blocking procedures. The results will help identify the most effective way to manage pain in older patients with rib fractures. The goal is to reduce side effects from pain medications, improve recovery and overall health outcomes, and guide healthcare professionals in choosing the best pain management approach for this patient group.

This study will evaluate the effectiveness and cost-effectiveness of Partners in Parenting Plus – Education (PiP-Ed+), a clinician-supported online parenting intervention designed to support parents of adolescents experiencing emotionally based school avoidance. This study is a prospective, parallel-group, waitlist controlled, randomised controlled trial. Eligible participants are parents of adolescents (aged 12-15) experiencing emotionally based school avoidance. Participants will be randomly allocated to either the PiP-Ed+ intervention or a 7-month waitlist control condition. The intervention includes a web-based parenting program and structured clinician-delivered coaching sessions, both of which target modifiable parenting behaviours and parental self-efficacy, with the aim of improving adolescent school engagement and mental health outcomes. Outcomes will be measured via parent and adolescent online surveys at baseline and follow-ups. The primary outcomes are parental self-efficacy to respond to adolescent school refusal and adolescent school attendance. Secondary outcomes include adolescent anxiety and depression, adolescent self-efficacy for school situations, parental mental health, parent and adolescent quality of life, parent satisfaction with PiP-Ed+, and cost-effectiveness of the intervention.

This study aims to compare two 8-week resistance training programs to see which better improves daily activities, strength, and well-being in healthy older adults aged 60 to 85. Participants will be randomly assigned to one of two training groups. The first group will use Velocity-Based Training (VBT), a method that adjusts training loads based on real-time movement speed. The second group will follow traditional strength training guidelines recommended by the American College of Sports Medicine (ACSM). We hypothesise that the VBT method will be more effective in enhancing neuromuscular qualities and daily functioning compared to the traditional ACSM approach.

This RCT aims to evaluate the feasibility and acceptability of daily consumption of a multi-ingredient high-protein beverage combined with a resistance exercise intervention in inactive older adults. Muscle function indicators, dietary intake and quality of life are also outcomes of interest. Research questions: (1) Is an intervention of 250mL high-protein beverage daily + resistance exercise twice weekly for 12 weeks feasible to older adults? (2) Is an intervention of 250mL high-protein beverage + resistance exercise twice weekly for 12 weeks acceptable to older adults? (3) Does an intervention of 250mL of low-protein beverage + resistance exercise twice weekly for 12 weeks improve muscle function parameters in healthy, physically inactive older adults? (4) Does an intervention of 250mL of high-protein beverage + resistance exercise twice weekly for 12 weeks result in a greater improvement in muscle function parameters in healthy, physically inactive older adults, compared to a low-protein beverage + resistance exercise intervention?

This study aims to assess whether postoperative anorectal pressures change over time and whether these changes differ according to the type of surgical procedure performed. Who is it for? You may be eligible for this study if you are a male or female aged 18 years or older who are undergoing colorectal surgery with formation of a primary colorectal anastomosis at Gold Coast University Hospital, including anterior resection or Hartmann’s reversal, and who are able to provide informed consent. Study details Those who are eligible will undergo anorectal pressure measurements using a small, single-use THD SensyProbe. Measurements will be taken once before surgery and then daily for up to five days after surgery, or until discharge from hospital if earlier. During each assessment, the probe will be gently inserted into the anal canal while the participant lies on their side, and resting anorectal pressure will be recorded. All participants will receive their planned surgery and standard postoperative care. There is no experimental treatment and no randomisation involved in this study. It is hoped that the findings will improve understanding of bowel function after colorectal surgery and help inform future strategies to reduce complications such as anastomotic leak.

Shoulder arthroscopy is commonly performed and postoperative pain can be substantial. The superior trunk block provides effective pain relief but may still impair diaphragm function in some patients. Although this is often well tolerated in healthy individuals, it may be clinically important in older or frail patients and those with pre-existing respiratory disease. Selective shoulder nerve blocks have been developed to target the nerves supplying the shoulder while potentially preserving diaphragm function, but clinical evidence supporting this approach remains limited. This randomised feasibility trial will compare the SAXIPec technique with the superior trunk block in adults undergoing elective shoulder arthroscopy. The primary aim is to determine whether a larger randomised controlled trial can be successfully conducted by assessing recruitment, successful delivery of the allocated intervention and completeness of follow-up. The study will also collect preliminary information on pain, quality of recovery, opioid consumption and diaphragm function to inform the design of a future definitive trial.

Parkinson’s disease is the fastest-growing brain disorder in the world. It can greatly affect people’s quality of life and put strain on carers. We still don’t know if a team-based rehabilitation approach works better than standard medical care. This small study (from May 2022 to November 2024) compared two approaches: the best medical treatment plus a team-based rehabilitation program, and the best medical treatment on its own.

Vial Australia Pty Ltd is conducting a first-in-human study of VIAL-IL13xTSLP, an experimental bispecific antibody that targets two inflammatory proteins (IL-13 and TSLP) involved in asthma. The study will evaluate the safety, tolerability, and biological effects of the drug in healthy volunteers.

Recent advancements in generative AI technology provide an opportunity to improve the quality and consistency of discharge summaries. This study aims to evaluate the use of generative AI in producing discharge summaries that conform to the National Guidelines for On-Screen Presentation of Discharge Summaries in Australia. This study will provide evidence on the potential benefits and risks of using generative AI to enhance the quality and efficiency of discharge summaries in Australian public hospitals, supporting the development of safer and more effective clinical documentation practices, in the event that AI products may contribute positively to the quality and timeliness of discharge summaries.