ANZCTR search results

This study evaluates MiM Primary Care, an online training programme designed to help GPs, nurses, pharmacists, and rural generalists better engage men in their care. Men are less likely to seek help early for health problems, and this training aims to build practitioners' knowledge, confidence, and skills in recognising and responding to men's health needs. We expect that completing the training will improve practitioners' knowledge and confidence in engaging male patients, measured using a purpose-built survey. All participating practitioners complete the training and are surveyed before training, immediately after, and again 12 weeks later, with no separate comparison group. The study will also examine whether the training is practical, acceptable, and likely to be adopted across different primary care settings.

This study is testing whether a simple daily self-care practice is realistic and manageable for busy health professionals — such as psychologists, counsellors, nurses, and other allied health practitioners — who often experience high levels of work-related stress. The practice, called SERF (Sensory Engagement and Reflective Practice for Flourishing), involves preparing and drinking a cup of herbal tea each day while doing a short breathing and reflection exercise, followed by a brief written reflection. Twenty-four health professionals will be randomly assigned to drink either Lemon Balm tea or Rooibos tea, alongside the same daily practice, for 28 days. Findings will help us design a bigger study and understand whether this kind of low-cost, self-guided practice could support the wellbeing of Australia's health workforce

This study aims to determine whether guselkumab is more effective than optimising current medical treatment for adults with stricturing Crohn's disease. Participants will be randomly assigned to receive either guselkumab or optimise their existing advanced medical therapy. We will compare how well these treatments improve bowel strictures, reduce the need for surgery, and improve symptoms and quality of life. We expect that guselkumab will be more effective at treating bowel strictures and slowing disease progression. This is the first randomised controlled trial specifically designed for people with stricturing Crohn's disease, a group that has largely been excluded from previous clinical trials.

Midline laparotomy closure techniques strongly influence postoperative wound outcomes, particularly incisional hernia, a frequent and clinically significant complication associated with pain, functional impairment, and reoperation. This is especially relevant in emergency laparotomy, where patients are physiologically compromised and at higher risk of contamination, infection, and impaired healing. We conduct this trial to compare small-bites versus large-bites fascial closure in emergency laparotomy to determine whether the benefits observed in elective and mixed surgical populations translate to this higher-risk setting.

This study aims to assess the feasibility of a randomised control trial to examine the efficacy of a novel rehabilitation protocol following acute ATR. The primary objective is to assess study feasibility via a) recruitment, conversion and retention rates, b) patient acceptability of the protocol, exercise prescription and testing, c) adherence to the exercise prescription, and d) adverse events. The secondary objective is to explore treatment effects in a) symptoms and disability related to the ATR, b) force output, c) tendon length and elongation, and d) High-density EMG (HD-EMG) muscle activity between groups at 16 and 26 weeks post-acute injury. Force output will only be tested at weeks 16 and 26, due to the viability of strength testing acute ATR.

This study is comparing three different types of biopsy needles used during an endoscopic ultrasound (EUS) procedure to collect tissue samples from solid pancreatic lesions Who is it for? You may be eligible to join this study if you are aged 18 years or above and require endoscopic ultrasound and tissue sampling of solid lesions in the pancreas for assessment of suspected pancreatic cancer. Study details All three needles used in the study are commercially available and routinely used in clinical practice, but it is not yet known which provides the best tissue sample for making an accurate diagnosis. Participants will be randomly allocated to one of the three needle types during their standard-of-care endoscopic ultrasound procedure. The study will compare how well each needle performs in obtaining tissue for diagnosis, how easy it is to use, and how safe it is. The Endoscopic Ultrasound Fine Needle Aspiration procedure will be assessed for the length of core sample taken, accuracy of diagnosis, tissue characteristics, and procedural time. It is hoped that the results from this study may help identify the most effective needle for EUS-guided tissue sampling and improve the diagnosis and management of patients with pancreatic lesions.

This clinical trial that looks at the effect of a weight loss medication (Semaglutide, more commonly known as Wegovy or Ozempic) on improving the exercise ability in patients with pulmonary arterial hypertension who have an elevated body mass index (BMI)

Brief description of the study purpose This study is investigating whether faecal microbiota transplantation (FMT) can improve the effectiveness of the immunotherapy drug cemiplimab in people with advanced cutaneous squamous cell carcinoma (cSCC). Researchers will also examine whether changes in the gut microbiome following FMT are associated with improved immune responses and better cancer outcomes. Who is it for? You may be eligible for this study if you are a male or female aged 18 years and older with locally advanced or metastatic cutaneous squamous cell carcinoma (cSCC) who have not previously received immunotherapy targeting PD-1, PD-L1 or CTLA-4 pathways and are suitable to undergo colonoscopic FMT. Study details All eligible participants will receive standard treatment with cemiplimab every three weeks, together with two faecal microbiota transplantation (FMT) procedures delivered by colonoscopy over a six-week period. All participants will also follow a study-prescribed whole-food, plant-enriched diet designed to support gut health throughout the study. All participants will receive the study treatment. Participants will be assigned to receive either a single-donor or two-donor FMT formulation. As part of the study, participants will undergo colonoscopies, blood tests, stool sample collection, questionnaires, and other assessments to monitor changes in the gut microbiome, immune system activity, treatment response, and safety. Participants will be followed for up to two years, with long-term safety monitoring continuing for up to ten years after study completion. It is hoped that this research will determine whether FMT can enhance responses to immunotherapy in advanced cSCC and contribute to the development of new treatment approaches for patients who currently have limited therapeutic options.

Psychological distress affects over one in five university students, harming their study, work, relationships, and wellbeing. Brief, smartphone-based programs targeting mindfulness, sleep, and physical activity can reduce distress, but not all students benefit equally. This study will explore whether “amotivation” – including low drive, loss of interest, and reduced social engagement – helps explain why some students respond less well to these interventions. Using our MindGRID digital phenotyping app, we will collect passive smartphone data (e.g., movement, location, phone use) alongside brief self-reports to identify digital patterns linked to amotivation. We will then test whether these digital profiles can predict and help personalise the delivery of smartphone interventions to improve mental health in university students.

This project seeks to enhance women’s access to primary care provision of LARC and EMA by addressing healthcare practitioner barriers and integrating these aspects of reproductive health into locally-available, community-based services. Lack of familiarity with LARC among health professionals and misperceptions about their use (e.g. many GPs falsely believe that IUDs are contraindicated in nulliparous women) have a profound effect on the advice given to women and limit women’s options. Lack of education and training for GPs and other health professionals and lack of follow-up support after training (e.g. supervision, mentoring) are also real issues. Further to this, integration of EMA into general practice has recognised barriers – some GPs feel EMA is beyond their scope of practice or that they would be stigmatised. Many feel isolated and speak of the need for peer support and referral pathways to assist them. It is anticipated with this intervention that primary care clinicians will benefit from the increased support and education, enhanced teamwork and networking with colleagues in the community, and connection to services and service providers to help women achieve their reproductive goals.