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This study investigates whether adding a brief, single-session intervention before admission can improve outcomes for young people aged 16 to 21 entering a sub-acute mental health service. Participants will receive a pre-admission session based on either Motivational Interviewing (MI) or Dialectical Behaviour Therapy Pre-Commitment (DBT-PC), and their outcomes will be compared with those receiving treatment as usual. The study will examine whether these interventions increase motivation to engage in therapy, as well as actual engagement during admission, measured through attendance at group and individual sessions and completion of homework. It will also assess whether the interventions lead to better clinical outcomes, including reduced suicide risk, increased psychological growth, and fewer hospital bed days or emergency department presentations at discharge and follow-up. Finally, the study will explore how motivation and engagement interact to influence the relationship between pre-admission symptoms and discharge outcomes, helping to clarify the role engagement plays in young people's mental health recovery.

This is a randomised, double-blind, placebo-controlled clinical trial designed to evaluate the efficacy of cannabidiol (CBD) compared with placebo in reducing alcohol consumption among adults with alcohol use disorder (AUD). Participants who have an Alcohol Used Disorder will be given bottles of CBD (or placebo) to take the recommended dose each day (a few drops, applied orally) for 12 weeks. Participants will attend for regular checks and drug dispensing during the treatment period. At Week 12, participants will have various checks to confirm whether drinking has reduced, again 12 weeks later an appointment will be held to check how participants have managed in the absence of the study drug .

Inpatient withdrawal management provides highly supportive care to allow people to safely and successfully complete their withdrawal episode. This duration of hospitalisation is of significant burden, both at the individual level and health system level. Expert consensus from the Clinical Directors of the five Local Health Districtss involved in this project have identified a potential solution – providing the option of a step-down model of care for patients admitted to hospital for alcohol and/or drug withdrawal. Based on clinical risk assessment, this would allow for patients to complete withdrawal in the community, reducing burden on hospital beds and allowing people to receive care from their own homes with access to personal supports. This project seeks to evaluate the impact of this change on length of stay and clinical outcomes using a stepped-wedge trial design where hospitals will randomly begin offering step-down care as an option to their patients over a 54 week period.

This trial compared two breathing therapies — high-flow nasal cannula (HFNC) and CPAP (the current standard treatment), to see whether HFNC was effective as well, and also tolerated for children with moderate-to-severe obstructive sleep apnoea. We also asked children which one they found more comfortable. Each child was studied for one night while sleeping, using sensors to measure how well they were breathing and sleeping on each therapy.

The study is testing a new internet-based health program that can be done from home. The aim is to find out if it helps improve important healthy actions (such as diet and exercise), as well as emotional wellbeing, in adults who have heart or blood vessel conditions or are at risk for these, and who also have symptoms of depression or anxiety. The program is psychologically-informed and designed to teach skills for setting goals, maintaining healthy actions in the long term, and overcoming common challenges.

The shortage of donors in heart transplantation remains a global issue. Recently, there has been significant advancement in the field of organ preservation including our recent study using hypothermic oxygenated perfusion (HOPE) in donation after brain death (DBD) donor hearts and clinical experience in heart transplantation using donation after cardiac death (DCD) donor hearts. We hypothesize that combining these methods will provide comparable outcomes to current techniques whilst increasing the number of heart donors to address the shortage of donor organs.

HeartPath+ is a digital educational resource for individuals who have experienced a coronary heart event. The early stages of transition from leaving hospital to coming home is a crucial time where many have felt uncertain and lacked information and support to manage their heart health and transition through to outpatient programs such as cardiac rehabilitation. HeartPath+ has been designed with lived experienced consumers. The aim is to empower and assist Australian living with heart disease and their family to actively manage their heart health.

This project is designed to assess the feasibility and acceptability of using Continuous Glucose Monitor Sensors (CGMS) in people with diabetes attending the Tweed Valley Hospital High Risk Foot Clinic Diabetes Multidisciplinary Team (TVH HRFC Diabetes MDT). The clinic comprises of the lead podiatrist, a diabetes educator and diabetes dietitian as well as consulting medical specialists including vascular, infectious disease, orthopeadic and endocrinology. The MDT clinic manages people with diabetes and active diabetes related foot ulcers, understanding the importance of achieving adequate glucose control to assist in the management of these wounds. The study protocol proposes a randomised feasibility trial where the intervention in the study is the use of CGMS within a cohort in the TVH HRFC Diabetes MDT and comparing this to another group that does not receive the CGMS. Both groups will otherwise receive the usual care that is provided within this clinic. We hypothesize that the use of the CGMS will assist to improve glucose control, improve diet quality, reduce diabetes distress and ultimately improve wound healing. Further, we believe that participants using the sensor will find the process acceptable and beneficial to their care.

Dental pain is a common condition that affects 1 in 5 Australians. Access to timely dental care is often difficulty, leading to many patients seeking care from the Emergency Department, where treatment options are often limited. This study aims to evaluate the use of a single dose of dexamethasone taken as a capsule to reduce pain in patients presenting to the Emergency Department with dental pain. Dexamethasone is a cheap and readily available medication that has few side effects and an excellent safety profile.

Traumatic brain injury (TBI) remains the leading cause of death after injury. In animal models, early treatment with plasma significantly attenuated neurological impairment after TBI. Early treatment with plasma is therefore a potential therapy for moderate to severe TBI that requires assessment in randomised trials. The aim of this study is to undertake a pilot RCT of early plasma versus standard care among patients with moderate to severe TBI.