ANZCTR search results

This study aims to understand how Long-COVID affects adults in Australia over time. Participants will be followed for up to 36 months after COVID-19 infection to assess changes in symptoms, functional ability, quality of life, social and broader psychosocial, behavioural and financial impacts using validated tools. The study will also examine factors associated with persistent symptoms and recovery. The findings will contribute to improved understanding of Long-COVID trajectories and may inform policy, clinical guidelines, and the development of care models for Long-COVID.

Sleep is regulated via two distinct but interrelated processes: homeostatic sleep and circadian processes. Circadian rhythms involve light-sensory neuro-hormonal signalling to intracellular clock mechanisms throughout the body. Despite major advances in the mechanistic understanding of the circadian rhythms, practical methods for daily circadian tracking do not exist. Tracking circadian timing accurately is essential for optimising treatments. The effects of circadian rhythm treatments depend critically on timing; interventions like bright light therapy and exogenous melatonin can either advance or delay circadian rhythms, depending on when they are applied relative to the phase response curve. Current clinical practice does not measure circadian timing reliably, as sleep specialists rely on guessing if and when to administer treatments based on self-reported sleep diary data and symptoms. This project aims to validate an array of wearable sensors for continuous core body temperature monitoring as a practical, affordable, and feasible method for daily circadian rhythm tracking. It also investigates the effectiveness of circadian-informed personalised light therapy versus standard care in treating delayed sleep-wake phase disorder.

New treatment option for post-surgery bleeding in ENT surgery patients undergoing sinonasal surgery. The potential treatment is Oral Tranexamic Acid (TXA) which has been used in other surgical disciplines to control post-surgery bleeding. The purpose of this study is to determine the effectiveness of oral TXA in preventing postoperative bleeding following sinonasal surgery and thereby decreasing discomfort and complications in the post operative period. This research clinical trial is a placebo-controlled drug trial. Both the treatment and placebo will look identical and participant nor the trial doctors will know which group you have been assigned to. The medication will be administered from 8am day 1 post-surgery as capsules. Two capsules will be administered 3 times a day for 3 days. Each capsule contains either 500mg TXA or placebo. Participants are allocated in a random 2 :1 ratio, thereby there will be 2 out of 3 chances of receiving the TXA study medication and 1 in 3 chances of being allocated placebo.

Rhinitis affects approximately 20 to 40% of the population and is currently poorly controlled in approximately 15% of the population with standard treatment. Botulinum toxin type A intra nasal spray could provide a painless, easily applied and potentially alternate treatment for sufferers. Currently there is wide use in cosmetic clinics but few supporting clinical trials. The overall aim of this study is to investigate the efficacy and safety of topical intranasal botulinum toxin type A in the treatment of refractory rhinitis when compared with a placebo.

This study aims to determine if a lower dose of botulinum toxin (Botox) (40 IU) is as effective as a higher dose (100 IU) for the treatment of chronic anal fissures. Eligible adult participants will be randomised to receive either a lower dose or a higher dose of Botox, injected into the anal sphincters under anaesthesia, and invited to participate in a 2-part simple questionnaire, the first part at the time of recruitment, and the second part at the final follow-up appointment at 12 weeks post-procedure.

Social prescribing is a holistic approach to healthcare that connects individuals with community resources and activities to address the social determinants of health, such as loneliness, isolation, and inactivity. The QLD Social Prescribing Trial is a first of its kind roll out of social prescribing through neighbourhood and community centres in 10 sites across QLD, funded by the Department of Communities under the Putting QLD Kids First initiative. The scope for inclusion is expectant mothers and parents/carers of children aged 0-18 years, and the children and young people aged 2-18 years experiencing loneliness and social isolation. These NC centres have been funded to engage social prescribing link workers, who will identify unique opportunities and pathways to enhance local families and young people’s quality of life by addressing their social needs. Over two years, we aim to conduct a comprehensive evaluation of this statewide social prescribing trial in Queensland. The objective is to evaluate the implementation process, track progress of families / individuals, and the overall success, sustainability, and scalability of the trial after implementation, with a focus on outcomes and economic analysis (cost / Quality of Life Years)

Patients with heart rhythm disorders potentially have an increased prevalence of frailty. Frailty influences treatment pathways such as pharmacotherapy in patients with AF for stroke risk and rate vs rhythm control. Patients who undergo ablation for AF who are also frail are more likely to have recurrence and are susceptible to events during hospitalisations. Patients who have cardiac device implantations are at increased risk of infection following surgery. As there are multiple aspects of heart rhythm disorder treatments that are influenced by frailty, we will determine the prevalence to help guide clinical screening requirements in this population.

Our group has recently undertaken studies of mega-dose intravenous sodium ascorbate in septic sheep (up to 3.75 g/kg) and demonstrated a dramatic reversal of organ dysfunction. We have recently completed a pilot study administering sodium ascorbate to critically ill patients with sepsis at a single dose of 60 grams over 6 hours. Sodium ascorbate was well tolerated, increased urine output, and decreased the requirement for medication to support the blood pressure (vasopressors). The study will determine whether mega-dose sodium ascorbate at a dose of 180 grams can decrease the time to weaning from blood pressure support for patients with sepsis and whether it improves other markers of organ dysfunction. If there is a signal for benefit, this trial will establish feasibility for a subsequent larger definitive study.

This study aims to see if using MarginProbe® radiofrequency spectroscopy device is practical in Australian hospitals and whether it affects surgery time and costs. Who is it for? You may be eligible for this study if you are a female aged 18 or older, you have histologically confirmed early-stage invasive breast cancer or ductal caricinoma in situ (DCIS). Planned breast-conserving surgery (wide local excision) with preoperative lesion localisation. Non-palpable disease. Able and willing to provide written informed consent and comply with study requirements. Study details All participants who choose to enroll in this study will be assessed by MarginProbe radiofrequency spectroscopy device during breast-conserving surgery. The device assesses all six surfaces of the excised tumour specimen for cancer cells; if positive, surgeon performs directed cavity shaves before closure. Participants will be followed up for 30 days for re-excision rate. It is hoped this study will help reduce the need for second operations and improves patient outcomes.

This study is a mixed-methods evaluation of child health services in rural Australia, examining accessibility, utilisation, quality, and coordination across primary, allied, and specialist care. It integrates administrative data analysis, caregiver and clinician surveys, semi-structured interviews, and geospatial mapping to identify system-level barriers, enablers, and inequities. Findings will inform evidence-based policy, workforce planning, and strategies to improve equity, efficiency, and culturally safe service delivery for children in rural regions.