ANZCTR search results

This study compares how the body absorbs leucine, a protein building block important for maintaining muscle health, after eating four protein-rich whole foods: boiled soybeans, natto, tempeh, and lean beef. The study is conducted in healthy older adults, a population particularly susceptible to age-related muscle loss. We aim to investigate (i) whether boiled soybeans lead to less leucine absorption in the body than lean beef, and (ii) whether fermenting soy, as in natto and tempeh, improves leucine absorption compared to non-fermented soybeans. We will also record how palatable each meal is and monitor participants' gastrointestinal comfort after eating. Findings will help determine whether fermented soy foods could serve as a practical plant-based alternative to beef for supporting muscle health in older adults.

This study evaluates the IIUIH System of Care version 2 (ISoC2), an Indigenous designed client-centred model of primary health care implemented by an Aboriginal and Torres Strait Islander community-controlled health service in Southeast Queensland. The model focuses on relational care, strengthening relationships between clients and care teams and supports strengths-based approaches to care. The study examines whether ISoC2 is associated with improvements in access to care, quality of care, and health and wellbeing outcomes for clients, including chronic disease management. It also evaluates how the model works in practice, including barriers and enablers to implementation, and whether it is cost-effective. This is an evaluation of a reformed system of care led by an Aboriginal and Torres Strait Islander community-controlled health service, aimed at ensuring services continue to deliver culturally grounded, relational, and strengths-based care while improving outcomes over time. Data are collected using routinely collected health records, client surveys, and yarning with clients and staff. The recruitment start date (01/01/2016) reflects commencement of routine clinical data capture within the MMEx electronic medical record by IUIH clinicians, rather than the later study implementation date. All participant data were collected during routine care and accessed for research following ethics approval. A waiver of consent was granted under the Public Health Act (PHA), with data custodian approvals (including IUIH and Queensland Health Statistical Services Branch) to enable data extraction and linkage to hospital admissions and emergency department datasets.

This study is testing whether a new prehabilitation program is acceptable and useful for people having a major surgery (i.e., free flap reconstruction) for head and neck cancer. Who is it for? You may be eligible for this study if you are an adult undergoing head and neck free-flap reconstructive surgery (any flap type) either for malignant or benign tumours or other benign conditions at Chris O'Brien Lifehouse. Study details All participants will be supported before surgery with information, a screening checklist, and daily activities focused on nutrition, exercise, oral health, and wellbeing. This will be provided through a one-off contact at the pre-admission appointment. Participants will be asked to complete questionnaires and interviews evaluating their experience. It is hoped that findings from this study will help develop a prehabilitation program which is feasible, acceptable and effective in supporting head and neck cancer patients undergoing major reconstructive surgery.

This study will evaluate whether a brief online psychosocial screening questionnaire can help identify these concerns earlier and connect young people to appropriate support. Young people aged 13–25 years with a chronic illness receiving care through participating hospital services will be invited to take part. Participants will complete online questionnaires about their health, wellbeing, and experiences of care. Those allocated to the screening group will also complete a brief psychosocial screening questionnaire, with any identified concerns reviewed by the clinical team according to usual care pathways with support, referral and ongoing care as appropriate. The study aims to determine whether routine psychosocial screening and targeted follow-up improves wellbeing, quality of life, and access to support services for young people with chronic illness.

The menstrual cycle is an important biological rhythm characterised by cyclical fluctuations in endogenous sex hormones such as estrogen and progesterone. These hormonal changes, along with associated symptoms, may influence training responses and adaptation. However, it remains unclear whether adjusting resistance training based on menstrual cycle phase or symptoms provides additional benefits compared to traditional training approaches. Therefore, this study aims to compare the effects of traditional training prescription (TRAD), menstrual cycle phase-based prescription (MCP), symptom-based autoregulatory prescription (AUTO), and a free-living control (FLC) on changes in muscular strength, power, and hypertrophy across an eight-week training intervention.

This study aims to compare traditional training prescription, menstrual cycle phase-based prescription, and symptom-based autoregulatory prescription on neuromuscular function, sleep and nocturnal physiology, and perceptions of well-being and training load. Participants completed a resistance training program lasting approximately 8-weeks. Countermovement jump performance, well-being, and session rating of perceived exertion (sRPE) were assessed at each training session, while sleep and nocturnal physiology were monitored daily throughout the intervention. It is currently unknown how recovery responses to resistance training prescribed based on menstrual cycle phase or symptoms differed from those following traditional training approaches.

HF-REACH is a study evaluating whether a nurse-led digital heart failure program can help reduce worsening heart failure compared with usual care. People taking part will either receive support from the CardioNexus nursing team using a mobile app or continue with their usual care. The program includes daily monitoring, education, and support from experienced heart failure nurses. We believe that this approach will help identify changes in health earlier and reduce heart failure-related emergency department visits and hospital admissions. The study aims to improve access to high-quality heart failure care for people living in regional Australia.

Rural Australians face significantly higher risk of suicide and trauma exposure compared to the general population (Kennedy et al., 2014; Miller & Burns, 2008; Milner et al., 2017), yet have limited access to mental health support. The MemFlex program offers a potential solution to challenges of accessibility and engagement in mental health care within rural Australia. MemFlex is a web-based, primarily self-directed treatment program that refocuses individuals towards positive memories from their past. Previous research has demonstrated the efficacy of the MemFlex in reducing symptoms of depressive and post-traumatic stress disorders (Hitchcock et al., 2021; Moradi et al., 2021). Here, we evaluate the acceptability and feasibility of offering a peer-led version of MemFlex to rural Australians experiencing psychological distress.

Some patients are difficult to insert an intravenous cannula into. These patients may experience multiple cannulation attempts, pain, anxiety, delayed treatment, and the need for more experienced clinicians or ultrasound-guided cannulation. This study will test whether it is feasible to use a patient-held Difficult Intravenous Access (DIVA) card for adults who are identified as having difficult intravenous access at Sir Charles Gairdner Hospital. Participants will be randomly allocated to either receive a DIVA card in addition to standard care, or to receive standard care without a DIVA card. The DIVA card is designed to help patients communicate their difficult intravenous access history to healthcare staff during future cannulation episodes. The study will assess whether patients can be recruited, whether they use the DIVA card, whether follow-up information can be collected by text message surveys, and whether the study procedures are practical for a larger future trial. The study will also collect early information about cannulation outcomes, such as first-attempt success, number of attempts, pain, escalation to senior clinicians or vascular access staff, and use of ultrasound-guided cannulation. Patient interviews will also be used to explore participant experiences of difficult cannulation and their views on the DIVA card.

Non-suicidal self-injury (NSSI) is a common mental health concern, yet many individuals do not disclose their experiences due to stigma, fear of negative reactions, and uncertainty about whether disclosure is the right choice. Disclosure can facilitate access to support and professional care; however, no decision-support tool currently exists to assist individuals in making informed decisions about NSSI disclosure. This study will evaluate the effectiveness of FIND (Facilitating Informed NSSI Disclosures), a web-based decision-aid tool designed to support informed, values-based decisions about whether, when, how, and to whom to disclose NSSI. In a three-arm randomised controlled trial, 200 participants aged 16 years and older with a lifetime history of NSSI will be allocated to FIND, a disclosure-focused psychoeducation resource, or a general NSSI psychoeducation resource. Outcomes will be assessed at baseline, post-intervention, and one-month follow-up, with preparedness to disclose NSSI as the primary outcome. Findings will determine whether FIND improves disclosure decision-making and may inform future interventions aimed at enhancing help-seeking, access to support, and early intervention among individuals who self-injure.