ANZCTR search results

Vial Australia Pty Ltd is conducting a first-in-human study of VIAL-IL13xTSLP, an experimental bispecific antibody that targets two inflammatory proteins (IL-13 and TSLP) involved in asthma. The study will evaluate the safety, tolerability, and biological effects of the drug in healthy volunteers.

Recent advancements in generative AI technology provide an opportunity to improve the quality and consistency of discharge summaries. This study aims to evaluate the use of generative AI in producing discharge summaries that conform to the National Guidelines for On-Screen Presentation of Discharge Summaries in Australia. This study will provide evidence on the potential benefits and risks of using generative AI to enhance the quality and efficiency of discharge summaries in Australian public hospitals, supporting the development of safer and more effective clinical documentation practices, in the event that AI products may contribute positively to the quality and timeliness of discharge summaries.

This study compares how the body absorbs leucine, a protein building block important for maintaining muscle health, after eating four protein-rich whole foods: boiled soybeans, natto, tempeh, and lean beef. The study is conducted in healthy older adults, a population particularly susceptible to age-related muscle loss. We aim to investigate (i) whether boiled soybeans lead to less leucine absorption in the body than lean beef, and (ii) whether fermenting soy, as in natto and tempeh, improves leucine absorption compared to non-fermented soybeans. We will also record how palatable each meal is and monitor participants' gastrointestinal comfort after eating. Findings will help determine whether fermented soy foods could serve as a practical plant-based alternative to beef for supporting muscle health in older adults.

This study evaluates the IIUIH System of Care version 2 (ISoC2), an Indigenous designed client-centred model of primary health care implemented by an Aboriginal and Torres Strait Islander community-controlled health service in Southeast Queensland. The model focuses on relational care, strengthening relationships between clients and care teams and supports strengths-based approaches to care. The study examines whether ISoC2 is associated with improvements in access to care, quality of care, and health and wellbeing outcomes for clients, including chronic disease management. It also evaluates how the model works in practice, including barriers and enablers to implementation, and whether it is cost-effective. This is an evaluation of a reformed system of care led by an Aboriginal and Torres Strait Islander community-controlled health service, aimed at ensuring services continue to deliver culturally grounded, relational, and strengths-based care while improving outcomes over time. Data are collected using routinely collected health records, client surveys, and yarning with clients and staff. The recruitment start date (01/01/2016) reflects commencement of routine clinical data capture within the MMEx electronic medical record by IUIH clinicians, rather than the later study implementation date. All participant data were collected during routine care and accessed for research following ethics approval. A waiver of consent was granted under the Public Health Act (PHA), with data custodian approvals (including IUIH and Queensland Health Statistical Services Branch) to enable data extraction and linkage to hospital admissions and emergency department datasets.

This study is testing whether a new prehabilitation program is acceptable and useful for people having a major surgery (i.e., free flap reconstruction) for head and neck cancer. Who is it for? You may be eligible for this study if you are an adult undergoing head and neck free-flap reconstructive surgery (any flap type) either for malignant or benign tumours or other benign conditions at Chris O'Brien Lifehouse. Study details All participants will be supported before surgery with information, a screening checklist, and daily activities focused on nutrition, exercise, oral health, and wellbeing. This will be provided through a one-off contact at the pre-admission appointment. Participants will be asked to complete questionnaires and interviews evaluating their experience. It is hoped that findings from this study will help develop a prehabilitation program which is feasible, acceptable and effective in supporting head and neck cancer patients undergoing major reconstructive surgery.

This study will evaluate whether a brief online psychosocial screening questionnaire can help identify these concerns earlier and connect young people to appropriate support. Young people aged 13–25 years with a chronic illness receiving care through participating hospital services will be invited to take part. Participants will complete online questionnaires about their health, wellbeing, and experiences of care. Those allocated to the screening group will also complete a brief psychosocial screening questionnaire, with any identified concerns reviewed by the clinical team according to usual care pathways with support, referral and ongoing care as appropriate. The study aims to determine whether routine psychosocial screening and targeted follow-up improves wellbeing, quality of life, and access to support services for young people with chronic illness.

The menstrual cycle is an important biological rhythm characterised by cyclical fluctuations in endogenous sex hormones such as estrogen and progesterone. These hormonal changes, along with associated symptoms, may influence training responses and adaptation. However, it remains unclear whether adjusting resistance training based on menstrual cycle phase or symptoms provides additional benefits compared to traditional training approaches. Therefore, this study aims to compare the effects of traditional training prescription (TRAD), menstrual cycle phase-based prescription (MCP), symptom-based autoregulatory prescription (AUTO), and a free-living control (FLC) on changes in muscular strength, power, and hypertrophy across an eight-week training intervention.

This study aims to compare traditional training prescription, menstrual cycle phase-based prescription, and symptom-based autoregulatory prescription on neuromuscular function, sleep and nocturnal physiology, and perceptions of well-being and training load. Participants completed a resistance training program lasting approximately 8-weeks. Countermovement jump performance, well-being, and session rating of perceived exertion (sRPE) were assessed at each training session, while sleep and nocturnal physiology were monitored daily throughout the intervention. It is currently unknown how recovery responses to resistance training prescribed based on menstrual cycle phase or symptoms differed from those following traditional training approaches.

HF-REACH is a study evaluating whether a nurse-led digital heart failure program can help reduce worsening heart failure compared with usual care. People taking part will either receive support from the CardioNexus nursing team using a mobile app or continue with their usual care. The program includes daily monitoring, education, and support from experienced heart failure nurses. We believe that this approach will help identify changes in health earlier and reduce heart failure-related emergency department visits and hospital admissions. The study aims to improve access to high-quality heart failure care for people living in regional Australia.

Rural Australians face significantly higher risk of suicide and trauma exposure compared to the general population (Kennedy et al., 2014; Miller & Burns, 2008; Milner et al., 2017), yet have limited access to mental health support. The MemFlex program offers a potential solution to challenges of accessibility and engagement in mental health care within rural Australia. MemFlex is a web-based, primarily self-directed treatment program that refocuses individuals towards positive memories from their past. Previous research has demonstrated the efficacy of the MemFlex in reducing symptoms of depressive and post-traumatic stress disorders (Hitchcock et al., 2021; Moradi et al., 2021). Here, we evaluate the acceptability and feasibility of offering a peer-led version of MemFlex to rural Australians experiencing psychological distress.