ANZCTR search results

The world’s population is getting older, and ageing is associated with a decline in cognition and blood circulation within the brain. This means that more people will require additional care or move into aged care facilities. Studies have shown that both cannabidiol (a non-intoxicating part of the cannabis plant) and vitamin E have the ability to improve blood flow throughout the body, particularly in the brain. This is important, because our brain requires a large percentage of our blood flow to supply it with all the oxygen and energy it needs. Through a randomised controlled trial, we will investigate the effect of cannabidiol and vitamin E on brain blood vessel function to improve cognition, over 16 weeks, anticipating that it will improve blood vessel function and cognition. It is hypothesised that both cannabidiol and vitamin E will each improve cognition and in this cohort by improving cerebrovascular function, as well as improving cardiovascular function and general physiological and psychological markers of health. It is also hypothesised that the combination of cannabidiol and vitamin E will improve cerebrovascular function and cognition as well as improving cardiovascular function and general physiological and psychological markers of health, beyond what either product achieves on its own. Your participation will help us determine if cannabidiol and vitamin E could be supplements that improve brain health. This work may help benefit yourself and others within your community to increase quality of life.

Adolescence is a crucial period for prevention efforts as numerous social and biological changes confer risk for mental health and substance use challenges, which can have enduring impacts across the life course. The Mind Your Mate Program was developed with youth, education and health experts to promote peer support, encourage help-seeking and prevent mental health and substance use problems in adolescents. Building upon the success of the pilot trial, which found significant reductions in adolescent depression, the program has been expanded into a comprehensive universal, school-based program. The new program will be evaluated through a cluster-randomised controlled trial conducted across secondary schools in Australia. We hypothesise, that compared to students receiving health education as usual, students in schools allocated to the program will show improved mental health knowledge and reduced mental ill-health risk.

This clinical trial looks into investigating the effectiveness of a novel group intervention programme for mild traumatic brain injury (mTBI or concussion) to help us provide better clinical care. The study involves a three-part intervention programme comprising 1) a neuropsychological examination measuring different aspects of cognition; 2) 6x1.5-hour weekly group sessions covering a range of information about mTBI, including skills that you can use to assist with recovery; and 3) up to 6x1-hour weekly individual sessions, in which some of the issues specific to your recovery will be addressed. Participants will also be asked to fill out a range of questionnaires at pre- and post-intervention, as well as a remotely administered 3-month follow-up, to track recovery progress.

This study is a randomised open-label trial of adminstering either Flucelvax (standard) and Fluad (adjuvanted) influenza vaccines. We will enrol healthy participants aged 18-50 years who did not receive any influenza vaccine in the 15 months preceding study entry and who would like to receive a 2026 influenza vaccine. We will randomise participants to receive either Flucelvax or Fluad Influenza vaccines and have blood, saliva and nasal fluid tests to follow their immune responses to the vaccines. Participants have study visits just prior to vaccination and on days 6, 28 and 180 post-vaccination. We are testing the idea that younger people who receive an adjuvanted influenza vaccine may have stronger immune reponses against a larger range of influenza virus strains

We are studying how much blood pressure and blood sugar vary across nights in people who have both obstructive sleep apnoea and high blood pressure. We want to see whether using a continuous positive airway pressure (CPAP) machine every night for about eight hours can help keep these levels more stable. We will look at how CPAP affects people’s blood pressure, blood sugar, and energy levels, both in a controlled laboratory setting and during everyday life at home. We will also explore whether factors such as diet, sleep habits, or teeth grinding influence these changes.

This study aims to evaluate the use of smaller-calibre endoscopic equipment during routine ureteroscopy and laser treatment for kidney and ureteric stones. Smaller instruments may allow the procedure to be completed more easily and with higher rates of success. The main aim is to assess whether these procedures can be completed successfully without use of pre-operative ureteric stents, and potentially also post-operatively, while monitoring procedural safety and short-term complication outcomes.

The closure of corneal wounds during cataract surgery remains reliant upon sutures, self-sealing corneal incisions, or tissue adhesives. Each of these methods have disadvantages, including time-consuming procedures, distortion of the eye’s shape, increased risk of endophthalmitis, wound leaks, lack of mechanical strength and toxicity to the ocular surface. We have developed a thin, laser-activated chitosan adhesive film that can be rapidly applied to the eye for sutureless sealing of corneal wounds. In this study, we propose to demonstrate the safety and efficacy of our adhesive film-based technology, termed ‘Kleer-i’, in sealing corneal wounds for the treatment of corneal wound incisions created during cataract surgery. The film may allow for quicker surgery, rapid healing and prevent the risk of complications such as scarring, infection and wound leakage.

This is a double-blind, placebo-controlled, First-In-Human Study of the safety, tolerability, pharmacokinetics of LW-1017 in Healthy Volunteers. Who is it for? You may be eligible for this study if you are aged between 18 to 80 years old and are in good general health without a clinically significant medical history. Study details Healthy volunteers will be randomly assigned to receive single or multiple oral doses of LW-1017 or placebo. Participants will undergo regular safety assessments, including vital signs, blood and urine tests, and other clinical evaluations. The purpose of this first-in-human study is to evaluate the safety, tolerability, and pharmacokinetics of LW-1017 and to identify dose levels suitable for future clinical studies. If results are acceptable, subsequent studies may evaluate LW-1017 in patients with Alzheimer’s disease or Parkinson’s disease.

This trial aims to assess the feasibility of delivering a once-off co-designed online learning module to promote and support healthy sleep practices among graduate nurses and midwives.

Amino acid sweat loss during high-intensity exercise in hot conditions may contribute to muscle fatigue and slower recovery after strenuous activity. The purpose of this project is to examine differences in post-exercise recovery, as measured by maximum voluntary isometric contraction (MVIC) of knee extensors and subjective fatigue rating, between intra-session HDAA supplementation and placebo. The aim is to examine the effect of HDAA supplementation against placebo in recreationally trained male and female cyclists. This study is a randomised, double-blind, crossover design involving two conditions: high-demand amino acid (HDAA) supplementation and a BCAA placebo control. Participants will be healthy recreationally trained cyclists 18-45 years of age. Objective and subjective measures of fatigue will be used to assess the effectiveness of the HDAA supplement compared to placebo in mitigating fatigue following strenuous exercise in the heat. Sweat will be collected and analysed for electrolyte concentrations during each exercise bout to examine relationships with electrolyte loss. Finally, muscle oxygenation will be used to examine the change in oxygenation patterns with supplementation.