ANZCTR search results

This study will test whether a brief online guided imagery exercise can help reduce maladaptive perfectionism in first-year university students. Participants will be randomly allocated to complete either an audio-guided imagery rescripting exercise or an audio-guided positive imagery exercise. They will complete online questionnaires before and after the exercise, and again after receiving their academic results.

This pilot evaluation will generate empirical evidence on the efficacy of the SCMH program in supporting parents of children from CALD backgrounds. The findings will also generate critical cultural considerations necessary to optimise the program’s relevance and appropriateness within CALD communities, which may lead to greater uptake of the course and better effects in CALD communities in Australia and internationally.

This randomised controlled trial aims to evaluate the effects of weight loss, via treatment with tirzepatide, combined with a personalised exercise intervention on markers of brain inflammation. This study will allow us to explore the link between excessive adiposity-induced systemic chronic inflammation, metabolic abnormalities, and neuroinflammation. We hypothesise that tirzepatide and exercise will result in attenuated neuroinflammation (as measured by neuroimaging), improvements in cognitive function, improvements in immune-inflammatory markers, and improvements in cardiometabolic biomarkers at 6 months compared to control.

Adults with epilepsy often face memory issues and reduced quality of life despite medical treatments for seizures, with few evidence-based non-drug options available in Australia. This randomised controlled trial tests if the HOBSCOTCH telehealth program (8 weekly sessions of self-management and cognitive strategies) improves quality of life compared to usual care for people living with epilepsy. We hypothesise that completion of the HOBSCOTCH program will result in improvements in quality of life compared to standard care, and will also result in improvements in self-efficacy, mood, and everyday cognitive function in patients with epilepsy. Furthermore, HOBSCOTCH will be feasible and able to be implemented within existing tertiary epilepsy services in Australia. Finally, we predict that HOBSCOTCH is cost-effective.

This study aims to investigate whether a safe, non-invasive form of brain stimulation delivered at home can improve attention in children and young people aged 8–24 years following an acquired brain injury. Participants will be randomly assigned to receive one of two types of brain stimulation or a sham (placebo) stimulation while completing a computer-based attention training activity for 20 minutes a day over 10 weekdays. The first and last sessions will take place at the research centre, while the remaining sessions will be completed at home under video-call supervision from the research team. Participants will also complete assessments of attention, hand function, and brain activity before and after the intervention, as well as one week later to determine whether any effects are maintained. We hypothesise that active brain stimulation combined with attention training will lead to greater improvements in attention compared with sham stimulation. The findings from this study may help inform the development of safe and accessible therapies to support cognitive recovery following childhood-acquired brain injury.

This is a pilot randomised controlled trial study. Twenty participants with a clinical or imaging-based diagnosis of endometriosis who are scheduled for laparoscopic excision surgery will receive a pre-operative course of home-based tDCS (active or sham). The primary purpose is to assess feasibility metrics and obtain preliminary effect size estimates to power a subsequent randomised controlled trial.

Guided by the RE-AIM framework, this multi-phase implementation study translates CIRCuiTS into routine mental health practice and examines the reach, adoption, implementation, effectiveness, and sustainability of the CIRCuiTS cognitive remediation therapy program for people with psychosis across four Australian public mental health services.

There are many models of maternity care available in Victoria. The model of care during pregnancy and the model of care at the onset of labour/admission to hospital for the birth is reported to the Victorian Perinatal Data Collection for all births This project will use this population-based dataset to analyse: -characteristics of women using the various models of care (e.g. residential location, age group, Aboriginal status, complexity of their pregnancy); -variation between models of care in the nature of the care provided (e.g. number of visits, maternal vaccinations in pregnancy); -differences in intrapartum care; -outcomes of the various models for women and for babies (e.g. mode of birth, maternal and neonatal complications, early infant feeding). All other models will be compared with private obstetric care.

This study will test whether a conservative treatment called full coronal pulpotomy can successfully save painful, deeply decayed adult teeth, even when some bleeding from the nerve tissue is deliberately allowed to continue before sealing the tooth. In this procedure, the dentist removes the inflamed nerve tissue from the crown of the tooth, places a modern bioactive cement over the remaining healthy pulp, and restores the tooth with a permanent filling, then reviews patients at 6 and 12 months to check pain levels, tooth function, and X-ray healing. The purpose is to see if this approach provides tooth survival and symptom relief that are not worse than those reported for conventional vital pulp therapy and standard root canal treatment, within a preplanned 10% margin. The study hypothesis is that allowing intentional uncontrolled bleeding (intentional uncontrolled haemostasis) during full coronal pulpotomy in these teeth will not lead to inferior 6 months or 12-month clinical and radiographic outcomes compared with published results for conventional vital pulp therapy and nonsurgical root canal treatment.

Gout is a painful form of arthritis caused by urate crystal deposition and is common in people with kidney failure receiving haemodialysis. Allopurinol is routinely prescribed to lower urate levels and prevent flares. However, haemodialysis itself removes urate, raising the possibility that some patients may no longer require allopurinol.. This pilot study will evaluate whether gradually stopping allopurinol is safe, effective, and feasible in haemodialysis patients with well-controlled gout. Participants will undergo stepwise dose reduction with regular blood tests and receive medication to prevent gout flares during the process. If a flare occurs, dose reduction will be stopped and usual treatment resumed. The study aims to reduce medication burden in this population and inform the design of a larger clinical trial and future clinical guidelines.