ANZCTR search results

A prospective, blinded, randomised split-face trial was performed, evaluating the effect of topical Arnica cream on postoperative periorbital ecchymosis and oedema following open septorhinoplasty. Each participant served as their own control, with Arnica applied to one hemiface and no treatment applied to the contralateral side This study tested whether arnica cream reduces bruising and swelling around the eyes after a nose job. To make it a fair test, it was planned ahead of time and ensured neither the patients nor the evaluating doctors knew which side of the face received the treatment. Each patient actually served as their own comparison; they applied the cream to one half of their face and left the opposite side completely untreated. By tracking the healing process on both sides, the study could directly measure if arnica cream truly speeds up recovery and lessens standard post-surgery black eyes and puffiness.

This study will be a pilot randomized clinical trial to assess whether magnetic acupuncture reduces pain prior to painful procedures (heel prick) in neonates. Neonates born at greater or equal to 29 weeks gestational age and/or greater or equal to 1,000 grams will receive either auricular magnetic acupuncture or placebo 30 minutes prior to a painful procedure (heel prick). Changes in cortisol levels and pain scores pre and post procedure will be evaluated both in the intervention and placebo groups. The purpose is to investigate non-pharmacological ways to reduce pain in neonates.

This study will compare a simple bladder test called single-channel cystometry with the standard multi-channel cystometry test used in urodynamic testing. Urodynamic testing is performed in women with bladder symptoms such as urgency, urinary leakage, difficulty emptying the bladder, or before some prolapse or continence operations. The standard multi-channel test measures pressures in both the bladder and abdomen. Single-channel cystometry is a simpler test that uses a single bladder catheter and sterile fluid to observe bladder filling, bladder sensations, bladder overactivity, and leakage with coughing. Women who are already having clinically indicated urodynamic testing will be invited to participate. All participants will have their usual multi-channel cystometry first as part of standard care. They will then have the additional single-channel cystometry test during the same appointment. The single-channel test is performed for research purposes only and will not be used to determine diagnosis or treatment. The main purpose of the study is to assess how accurately single-channel cystometry identifies detrusor overactivity, or bladder overactivity, and urodynamic stress incontinence, or leakage with increased abdominal pressure, compared with standard multi-channel cystometry. The study hypothesis is that single-channel cystometry will show acceptable diagnostic accuracy and agreement with multi-channel cystometry for detecting detrusor overactivity and urodynamic stress incontinence.

During Personalised External Aortic Root Support (PEARS) surgery, blood pressure is deliberately lowered for a prolonged period to allow safe placement of the external aortic support. This study will investigate how the brain regulates its blood flow during these periods of low blood pressure using non-invasive monitoring techniques. Researchers will determine whether each patient has an individual blood pressure threshold below which blood flow regulation becomes impaired. The study will examine whether time spent below this threshold is associated with postoperative complications, including delirium, kidney injury, heart injury, and changes on brain imaging. The findings will help determine whether personalised blood pressure targets may improve patient outcomes during future surgery.

This study aims to understand how genetic differences affect how Aboriginal and Torres Strait Islander people respond to commonly prescribed medications for chronic health conditions. Participants will undergo a simple blood test to identify genetic factors that may influence how their body processes medicines. The results will be provided to their doctor to help guide medication selection and dosing. The study will assess whether using this genetic information can improve medication safety and effectiveness by reducing adverse drug reactions and supporting better treatment decisions. We expect that pharmacogenomic-guided(PGx) care will lead to more personalised and safer medication use for participants.

Brief description of the study purpose This study aims to evaluate the safety, tolerability, pharmacokinetics, and food effect of a new investigational medicine called SCB0020160 in healthy adult men. This is the first time SCB0020160 will be administered to humans. Who is it for? Healthy adult men aged 18 to 65 years who meet the study eligibility criteria. Study details Participants will be randomly assigned to receive either SCB0020160 or placebo. The study includes single-dose and multiple-dose treatment periods, as well as an assessment of the effect of food on the absorption of SCB0020160. Participants will undergo safety assessments including physical examinations, vital signs, ECGs, blood and urine tests, and monitoring of adverse events. The study will also assess how SCB0020160 is processed by the body. There is no direct health benefit expected from participation. The results may help determine safe dose levels and support future clinical development of SCB0020160.

This study has undergone initial ethics review by the Edith Cowan University Human Research Ethics Committee and is currently under revision. Once revised and approved, it will be approved under the following ethics protocol number REMS No. 2025-07121-LEOW. Participants are healthy adults recruited voluntarily via the ECU and Curtin University SONA participant pools, campus flyers, and community advertising. Informed consent is obtained after participants have had unlimited time to review the Participant Information Letter and ask questions. A pre-screening questionnaire is completed prior to scheduling to ensure participant safety; participants are not required to specify which exclusion criteria apply to them, protecting privacy. All data are de-identified upon collection, stored on secure password-protected university servers, and retained for a minimum of 15 years in accordance with ECU's Data Management Policy for clinical trials.

This study evaluates whether the use of a block room (parallel processing model) for regional anaesthesia is associated with improved operating theatre efficiency in orthopaedic surgery. Using routinely collected theatre management system data from a tertiary hospital, patients are classified into three groups based on anaesthetic pathway: block before surgery, theatre block, and no block. The primary outcome is anaesthetic-controlled time, with secondary outcomes including time to readiness for surgery, post-anaesthesia care unit duration, and theatre turnover time. The study is a retrospective observational cohort analysis of cases performed between January 2023 and November 2025. Findings aim to provide contemporary Australian data to inform perioperative workflow optimisation and service planning.

The proposed research determines the effectiveness of an intervention to support nursing staff to share more meals in socially engaging ways as a strategy for reducing burnout. The main intervention comprises providing staff with “family”-size meal kits, that are healthy and encourage staff to share the meal with family or friends.

Medications can sometimes cause serious problems, like ending up in hospital or even death. People living in rural and deprived areas are more vulnerable to these problems. We aim to work with rural consumers and healthcare providers to develop a new computer support tool that will help health professionals find people who might be at risk because of their medicines. Then, doctors, nurses, and pharmacists can check these medications and make necessary changes to keep rural Australians safe.